Evidence map›Paper›PMID 39619581›Full record

ArticleHeliyon2024

Ciprofloxacin hydrochloride-loaded ocular silk fibroin liposomes: Formulation, characterisation,

Umer Mushtaq Bhat, Nisar Ahmad Khan, Syed Naiem Raza, Mohammad Ali, Seema Mehdi, Ishfaq Mohiuddin, Faiyaz Shakeel, Zulfikar Ali Bhat, Ghulam Nabi Bader, Ishtiaq Ahmad Chashoo and 1 more

Abstract read
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In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Umer Mushtaq BhatDepartment of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Srinagar, 190006, India.
Nisar Ahmad KhanDepartment of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Srinagar, 190006, India.
Syed Naiem RazaDepartment of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Srinagar, 190006, India.
Mohammad AliDepartment of Pharmacology, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G Nagar, Nagamagala, Bellur, Karnataka, 571418, India.
Seema MehdiDepartment of Pharmacology, JSS College of Pharmacy, Mysuru, 570015, India.
Ishfaq MohiuddinDepartment of Zoology, Annamalai University, Annamalainagar, 608002, India.
Faiyaz ShakeelDepartment of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
Zulfikar Ali BhatDepartment of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Srinagar, 190006, India.
Ghulam Nabi BaderDepartment of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Srinagar, 190006, India.
Ishtiaq Ahmad ChashooDepartment of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Srinagar, 190006, India.
Shahid Ud Din WaniDepartment of Pharmaceutical Sciences, School of Applied Sciences and Technology, University of Kashmir, Srinagar, 190006, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ocular drugs have low absorption because of the unique environment in the eye, making ocular drugs one of the most challenging pharmaceutical initiatives. Liposomes have shown to be a promising ocular drug delivery system over the years because of enhanced drug absorption, biocompatibility, and biodegradability. Utilising a mucoadhesive material alongside liposomes could be a promising strategy to increase the therapeutic efficacy of ocular drugs. The present study aimed to develop a silk fibroin (SF)-coated liposomal formulation as an ocular drug delivery system. Regenerated silk fibroin (a novel biopolymer) was coated on ciprofloxacin hydrochloride-loaded liposomes (CPH-SFLs). Studies were carried out on the morphology, drug encapsulation efficiency, and

Indexed as

Antimicrobial activityCiprofloxacin HClIn vitro cytotoxicityLiposomesOcular drug deliverySilk fibroin

Identifiers

PMID39619581
PMCPMC11605355

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.