ArticleACS omega2024
Protective Role of Melatonin against Liver Toxicity from Black Phosphorus Nanosheets via Oxidative Stress and Pyroptosis.
Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Black phosphorus nanomaterials induce hepatic lipid metabolism disorders by triggering oxidative stress and mitochondrial dysfunction.Particle and fibre toxicology · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the field of contemporary medicine, with the rapid application of nanomaterials, evaluating their biocompatibility and potential toxicity has become increasingly important. This study characterized black phosphorus nanosheets (BPNSs) and employed both in vivo and in vitro models to assess the impact of BPNSs exposure on oxidative stress and pyroptosis in hepatocytes. We investigated the hepatotoxicity of this emerging nanomaterial and the protective role of melatonin against BPNSs induced hepatocyte pyroptosis. The results showed that BPNSs exposure reduced hepatocyte viability, induced morphological changes, and elevated the expression of pyroptosis-related proteins, suggesting that BPNSs promote hepatocyte pyroptosis through the ROS-NLRP3-GSDMD pathway, thereby exacerbating the inflammatory response. Melatonin, a bioactive substance with anti-inflammatory and antioxidant properties, was found in our study to significantly mitigate these adverse effects. It emphasized the role of melatonin in regulating ROS production and related pathways, effectively protecting hepatocytes from BPNSs induced damage. This study elucidates the mechanistic link between BPNSs exposure and hepatocyte pyroptosis, emphasizing the efficacy of melatonin as a protective agent. It offers new insights for preventing BPNSs induced liver injury and provides a foundation for safer nanomaterial application strategies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.