Evidence map›Paper›PMID 39619385›Full record

ArticleJournal of carbohydrate chemistry2023

Syntheses of Propargyl Glycosides of Disaccharides of the Capsular Polysaccharides from Serotypes 4, 7F, and 9V

Seth A Taylor, Kendell White, Regan Patton, Anna Linder, Spencer Shin, Sophie Nelson, Jared Haymore, Joseph Zambrano, Marcus Hayden, Shawn Gubler and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of carbohydrate chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Seth A TaylorDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.
Kendell WhiteDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.
Regan PattonDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.
Anna LinderDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.
Spencer ShinDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.
Sophie NelsonDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.
Jared HaymoreDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.
Joseph ZambranoDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.
Marcus HaydenDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.
Shawn GublerDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.
Tianyao MengDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.
M G FinnSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA.
Luc TeytonDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA.
Shenglou DengDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.
Paul B SavageDepartment of Chemistry and Biochemistry, Brigham Young University, Provo, Utah, USA.

Funding

Development of the Next Generation of Conjugate VaccinesR01AI139748 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI TEYTON, LUC · 2018 to 2021
$3.4M
NIAID NIH HHS R01 AI139748
6 · The paper itself

Abstract

We have developed a means of presenting relatively small glycans in a context to make them T cell-dependent antigens. This approach requires synthesis of glycans that remain close to carrier proteins upon conjugation, allowing T cell recognition and generation of B cells that produce high-affinity antibodies and memory toward target pathogens. In this work, we describe the syntheses of three disaccharides of the capsular polysaccharides from serotypes 4, 7F and 9V

Indexed as

7F and 9Vcapsular polysaccharideglycan antigenserotypes 4Streptococcus pneumoniae

Identifiers

PMID39619385
PMCPMC11606575

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.