ArticlePsychiatry and clinical psychopharmacology2021
The Role of the Central and the Peripheral Neuropeptides in Weight Gain and Metabolic Changes Related to Olanzapine.
Article in Psychiatry and clinical psychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to examine the role of central and peripheral neuropeptides in olanzapine-induced weight gain and metabolic changes. Materials and Methods: Thirty patients who would receive olanzapine treatment were evaluated at the beginning of the treatment at the 2 Results: There were statistically significant differences weight and waist circumference levels compared to the initial levels. As observed in previous studies in the literature, changes in biochemical parameters including AST, ALT, total and direct bilirubin, LDL, TG, total cholesterol, and HDL levels were statistically significant. Levels of the neuropeptides POMC and NPY tended to increase at early stages and decrease at later stages of the treatment, while CCK and leptin levels kept increasing throughout the treatment period. The changes in POMC and CCK levels were statistically significant. Conclusion: The results suggest that POMC and CCK may play a role in olanzapine-related weight gain.
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