ArticleInternational journal of general medicine2024
Fibrinogen, FDP and D-Dimer as Potential Biomarkers for Disease Severity in Ulcerative Colitis: A Retrospective Study.
Article in International journal of general medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Elevated serum sortilin reflects inflammatory burden and coagulation dysfunction in ulcerative colitis.Frontiers in medicine · 2026Article
- NPHR, FPR, and PLT as predictors of ulcerative colitis severity: a single-center retrospective study in China.Frontiers in medicine · 2026Article
- Thrombosis and Anemia in Pediatric Inflammatory Bowel Disease: Pathophysiology, Clinical Impact and Future Directions.International journal of molecular sciences · 2025Review
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Authors and funding
6 authors.
Funding
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Abstract
Purpose: Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease that primarily affects the large intestine. Coagulation abnormalities have been detected in UC patients. This study aimed to evaluate coagulation-related parameters in patients with UC. Patients and Methods: A total of 364 UC patients were analyzed with 163 female and 201 male. Disease activity was determined according to the Truelove and Witts criteria. The fibrinogen (FIB), D-dimer, fibrin/fibrinogen degradation products (FDP), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels were evaluated. Results: We found higher D-dimer, FDP, FIB levels in severe UC compared with non-severe patients.The area under the curve (AUC) of D-dimer was 0.852 (95% CI 0.805 to 0.898) and the optimum cut-off point was 0.585, with a sensitivity of 80.6% and a specificity of 78.9%. Furthermore, D-dimer and FIB are positively correlated with ESR and CRP levels. Conclusion: Our results indicate that D-dimer, FDP, and FIB levels are potential biomarkers for disease severity in UC patients.
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