ArticleFrontiers in public health2024
Associations between smoking and coronary heart disease: mediating role of RDW.
Article in Frontiers in public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Distinct clinical profiles and outcomes in young versus older adults with acute coronary syndrome: a comparative cohort study.Journal of cardiothoracic surgery · 2026Article
- The Systemic Immune-Inflammation Index and High-Sensitivity C-Reactive Protein to High-Density Lipoprotein Cholesterol Ratio Predict Moderate and Severe Coronary Artery Stenosis in Older Patients with Coronary Heart Disease.Clinical interventions in aging · 2026Article
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Authors and funding
7 authors.
Funding
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Abstract
Introduction: Previous studies have demonstrated that both smoking and coronary heart disease (CHD) are linked to red cell distribution width (RDW). However, the role of the RDW in the association between smoking and CHD remains unclear. This study investigates the role of RDW in the association between smoking and coronary heart disease. Methods: Data from 13,080 adults aged 40-80 years were analyzed from the National Health and Nutrition Examination Survey (NHANES) conducted between 2006 and 2017. Statistical methods included regression analysis, restricted cubic spline curve (RCS), subgroup analysis, and mediation analysis. Results: Results showed higher RDW levels in participants with smoking and/or CHD than in those without. Smoking status was positively associated with RDW and CHD even after adjusting for potential confounders. A nonlinear relationship between RDW and CHD was observed ( Discussion: Our research showed that smoking, RDW, and CHD are interrelated, with RDW playing as a mediator, offering a novel perspective for the prevention and management of CHD.
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