ArticleCureus2024
Evaluation of the Anti-biofilm Activity of Vitamins Against Acinetobacter baumannii and Klebsiella pneumoniae Recovered From Clinical Specimens: An In Vitro and In Silico Analysis.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Vitamin D metabolites reshape bovine mammary epithelial responses relevant to mastitis through host-directed mechanisms.Frontiers in cellular and infection microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPathogens that form biofilms reduce the effectiveness of conventional treatments and promote antibiotic resistance. Therefore, this study aimed to investigate the antibiofilm properties of vitamin C (ascorbic acid) and vitamin D (cholecalciferol) experimentally.
methodsThe antibiofilm properties of the studied compounds were evaluated using molecular docking analyses. AutoDock Vina software (The Scripps Research Institute, La Jolla, California) was used to assess the binding affinity of vitamins C and D to the active sites of biofilm-related proteins.
resultsMolecular docking revealed different affinities toward the active sites of the target proteins. The interactions showed promising results, with vitamin D forming both hydrogen bonds and hydrophobic interactions. Compared to vitamin C, vitamin D exhibited the highest binding affinity, with a score of -10.8 kcal/mol.
conclusionHowever, molecular dynamics simulations are needed to further elucidate the dynamic behaviors and stability of these compound-protein complexes. Vitamin D demonstrated good in vitro potential as an anti-biofilm agent and should be considered for use alongside antibiotics in the treatment of bacterial infections.
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Registered trials
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