ArticleCureus2024
Hormonal Dynamics in Response to Short-Term Hypoxia Exposure: Cortisol and Prolactin Regulation as Adaptive Mechanisms.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Can a weekend of controlled hypoxia restore hormonal balance? A novel approach to stress recovery in aviation professionals.Frontiers in physiology · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe better availability of altitude rooms in hotels and sports centers led to increased people speculating that "over-the-weekend" hypoxia might contribute to overall psychological and physical well-being. PURPOSE: This study investigates the acute stress hormone response in management professionals following short-term exposure to normobaric hypoxia, amidst the increasing use of hypoxic conditions in stress-relief programs, which lack scientific validation.
methodsTwelve healthy male subjects, employees in management positions (mean age 34.72±7.43y), voluntarily agreed to participate in the within-subjects design study and were subjected to sleep and stay in normobaric hypoxia (simulating oxygen pressure at 2800m) twice, for at least 12h per exposure, over a total period of 48 hours to simulate popular "manager weekend hypoxia stays". The protocol included blood sampling 48 hours before intervention, on the morning of intervention, and immediately after finishing the hypoxia stay. We determined the concentrations of total testosterone, dehydroepiandrosterone-sulfate (DHEA-S), prolactin, and cortisol.
resultsA significant increase in prolactin (p=0.021) and cortisol (p=0.039) concentrations and a decrease in DHEA-S to cortisol ratio (p=0.034) were observed. DISCUSSION AND
conclusionShort exposure to normobaric hypoxia induces alterations in the hypothalamic-pituitary-adrenal and pituitary-gonadal axis showing significant stress response even though otherwise was expected due to participants' stressful jobs.
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Registered trials
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