Evidence map›Paper›PMID 39618480›Full record

ReviewCell insight2025

Just a SNP away: The future of

Katherine N Degner, Jessica L Bell, Sean D Jones, Hyejung Won

Abstract readReview
In one paragraph

Review in Cell insight, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The genetics of hypertension.Nature reviews. Nephrology · 2026
    Review
  5. Predictive design of tissue-specific mammalian enhancers that functionbioRxiv : the preprint server for biology · 2025
    Article
  6. Review
  7. Context-dependent regulatory variants in Alzheimer's disease.bioRxiv : the preprint server for biology · 2025
    Article
  8. AnFrontiers in genetics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Katherine N DegnerDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jessica L BellDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sean D JonesDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Hyejung WonDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Funding

RESEARCH TRAINING IN THE NEUROSCIENCEST32NS007431 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Juan Song, Mark J. Zylka · 1997 to 2026
$10.0M
Systematic in vivo characterization of disease-associated regulatory variantsUM1HG012003 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Michael Isaiah Love, KAREN L. MOHLKE · 2021 to 2026
$9.9M
Discovery and validation of genetic variation impacting the gene regulatory landscape during human cortical developmentR01MH122509 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STEIN, JASON LOUIS, WON, HYEJUNG · 2023 to 2025
$1.6M
NHGRI NIH HHS UM1 HG012003NIMH NIH HHS R01 MH122509NINDS NIH HHS T32 NS007431
6 · The paper itself

Abstract

The human genome is largely noncoding, yet the field is still grasping to understand how noncoding variants impact transcription and contribute to disease etiology. The massively parallel reporter assay (MPRA) has been employed to characterize the function of noncoding variants at unprecedented scales, but its application has been largely limited by the

Indexed as

In vivoMPRANeurodevelopmentalNoncoding genomePsychiatricSystemic

Identifiers

PMID39618480
PMCPMC11607654

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.