ArticleHypertension (Dallas, Tex. : 1979)2025
Definitive Evidence for the Identification and Function of Renin-Expressing Cholinergic Neurons in the Nucleus Ambiguus.
Article in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Neurocardiology: Brain-Heart Interactions in the Heart.MedComm · 2026Review
- The choroid plexus is a source of active renin in the central nervous system.Research square · 2026Article
- Brain and hypertension: from sympathetic outflow to brain-focused blood pressure management.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- The brain-heart axis: effects of cardiovascular disease on the CNS and opportunities for central neuromodulation.Nature reviews. Neuroscience · 2026Review
- Microglial activation and RAS signaling: a dual-edged sword in neuroinflammation.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Review
- Central nervous system mechanisms of salt-sensitive hypertension.Physiological reviews · 2025Review
- Physiological and Molecular Implications of Angiotensinergic Signaling in the Brainstem.Endocrinology · 2025Review
- Cellular and Molecular Architecture of Renin-Angiotensin System Signaling in the PVN Under Cardiometabolic Stress.bioRxiv : the preprint server for biology · 2025Article
- Cardiac vagal motor neurons.Current opinion in neurobiology · 2025Review
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Authors and funding
22 authors.
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Abstract
backgroundThe importance of the brain renin-angiotensin system in cardiovascular function is well accepted. However, not knowing the precise source of renin in the brain has been a limitation toward a complete understanding of how the brain renin-angiotensin system operates.
methodsHighly sensitive in situ hybridization techniques and conditional knockout mice were used to address the location and function of renin in the brainstem.
resultsWe identified novel renin-expressing cholinergic neurons in the nucleus ambiguus (NuAm), a major vagal cardioinhibitory center in the brainstem. The expression of renin-angiotensin system genes was relatively abundant in the NuAm, implying that angiotensin II might mediate an important regulatory role in this nucleus and other regions with neural connectivity to the NuAm. Then, we generated conditional knockout mice lacking the classical renin isoform (Ren-a
conclusionsThis study revealed that renin in cholinergic neurons plays a fundamental role in preserving autonomic balance and cardiovascular homeostasis in a sex-dependent manner. These findings define the NuAm as an endogenous, local source of renin with biological function and serve as conclusive evidence for the presence and functionality of the brain renin-angiotensin system.
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