Evidence map›Paper›PMID 39618333›Full record

ArticleJournal of cardiovascular electrophysiology2025

CineECG Repolarization Gradients Predict Acute Hemodynamic Response in CRT Patients.

Ksenia Sedova, Jan E Azarov, Peter M Van Dam, Lucie Necasova, Jan Kukla, Marek Sramko, Lukas Kryze, Josef Kautzner

Abstract readComparative Study
In one paragraph

Article in Journal of cardiovascular electrophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Ksenia SedovaDepartment of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, Kladno, Czech Republic.ORCID 0000-0003-0723-2675
Jan E AzarovDepartment of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, Kladno, Czech Republic.ORCID 0000-0003-1779-273X
Peter M Van DamCenter for Digital Medicine and Robotics, Jagiellonian University Medical College, Krakow, Poland.
Lucie NecasovaDepartment of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Jan KuklaDepartment of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Marek SramkoDepartment of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Lukas KryzeDepartment of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Josef KautznerDepartment of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

Funding

This study was supported by the project National Institute for Research of Metabolic and Cardiovascular Diseases (Programme EXCELES, Project No. LX22NPO5104) - Funded by the European Union - Next Generation EU. This work was also funded by the project (Ministry of Health, Czech Republic) for development of research organization 00023001 (IKEM, Prague, Czech Republic) - Institutional support and by the Czech Technical University in Prague (SGS22/203/OHK4/3T/17).
6 · The paper itself

Abstract

introductionA variable proportion of non-responders to cardiac resynchronization therapy (CRT) warrants the search for new approaches to optimize the position of the left ventricular (LV) lead and the CRT device programming. CineECG is a novel ECG modality proposed for the spatial visualization and quantification of myocardial depolarization and repolarization sequences.

objectiveThe present study aimed to evaluate CineECG-derived parameters in different pacing modes and to test their associations with acute hemodynamic responses in CRT patients. METHODS AND

resultsCineECG was used to construct the average electrical path within the cardiac anatomy from the 12-lead ECG. CineECG and LV dP/dt max were tested in 15 patients with nonischemic dilated cardiomyopathy and left bundle branch block (QRS: 170 ± 17 ms; LVEF: 26 ± 5.5%) under pacing protocols with different LV lead localizations. The CineECG-derived path directions were computed for the QRS and ST-T intervals for the anteroposterior (X

conclusionThe acute hemodynamic response in CRT patients was associated with specific CineECG repolarization sequence parameters, warranting their further testing as potential predictors of clinical outcomes.

Indexed as

Cardiac Resynchronization TherapyCardiac Resynchronization Therapy DevicesElectrocardiographyAgedFemaleHemodynamicsHumansMaleMiddle AgedMyocardial ContractionProspective Studiescardiac resynchronization therapyheart failurehemodynamicsmultipoint pacingmultisite pacingrepolarization

Identifiers

PMID39618333
PMCPMC11837882

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