ArticleHealth services research2025
Drivers of infliximab biosimilar uptake: A comparative analysis of new biosimilar initiations versus switching in a national rheumatology registry.
Article in Health services research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Major US Formulary Change Triggers, but Does Not Sustain, Increases in Biosimilar Adalimumab Prescribing.Arthritis care & research · 2026Article
- Navigating the Transition: A Scoping Review of System-Level Factors in Biosimilar Integration for Immune-Mediated Inflammatory Diseases.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026Article
- Drivers of infliximab biosimilar uptake: A comparative analysis of new biosimilar initiations versus switching in a national rheumatology registry.Health services research · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveTo analyze the variability in new infliximab biosimilar starts as well as switching from bio-originator to biosimilar infliximab, across insurance payers and rheumatology practices nationally. STUDY SETTING AND
designData came from Rheumatology Informatics System for Effectiveness, a national registry with electronic health records from over 1100 US rheumatologists. Key outcomes include ever use of a biosimilar, date of initiation, and date of switching. Key variables of interest include insurance payer and practice. DATA SOURCES AND ANALYTIC SAMPLE: Secondary analysis of 37,560 patients aged ≥18 years administered infliximab (bio-originator or biosimilar) between April 2016 and September 2022 in Rheumatology Informatics System for Effectiveness. We tested for differences in use of biosimilar infliximab by demographic characteristics, socioeconomic status, and diagnosis using standard mean differences and multivariable modified Poisson regression. We used generalized estimating equations to assess the adjusted effect of insurance and year of initiation on new biosimilar starts. We analyzed variation in biosimilar switching by insurance, date of switch, and practice. PRINCIPAL
findingsA total of 8196 (21.8%) infliximab users ever used a biosimilar and use did not differ significantly by demographic or clinical characteristics. In 2022, uptake among new users was higher among those with Medicaid (55%; 95%CI 43%-68%) and private insurance (51%; 95%CI 46%-57%) compared to Medicare (36%; 95%CI 29%-43%). Few prevalent bio-originator infliximab users switched to a biosimilar, and switching was lowest among Medicare beneficiaries (7% vs. 14.2% in Medicaid and 16.9% among privately insured). In adjusted analyses, practice level differences explained 37% of variation among new biosimilar starts and 34% of variation among those switching to a biosimilar.
conclusionsOur findings underscore two critical areas for enhancing biosimilar infliximab usage: increasing switching among prevalent users and increasing uptake among Medicare beneficiaries initiating treatment. Significant variation in uptake across practices also suggests that local switching policies are likely key drivers of uptake.
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