ArticleClinical oral investigations2024
Investigation of the association between COX-2 polymorphisms and external apical root resorption in orthodontically treated patients.
Article in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Association Between Single-Nucleotide Polymorphisms and DRAM1 Gene Expression in Periodontal Ligament Fibroblasts Under Orthodontic Compression.Biomedicines · 2026Article
- The pivotal role and intervention strategies of BMAL1 mediated circadian clock dysregulation in intervertebral disc degeneration.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectiveTo evaluate the association between single nucleotide polymorphisms (SNPs) in cyclooxygenase-2 (COX-2) and external apical root resorption (EARR) after orthodontic treatment. MATERIALS AND
methodsThis study analyzed the orthodontic records of patients from Regensburg University Hospital and two collaborating private practices. EARR was analyzed in the maxillary central incisors and first mandibular molars using pre- and post-treatment cephalometric and panoramic radiographs, respectively. Genomic DNA was obtained from salivary oral cells. Two SNPs in COX-2, rs5275 (3 prime untranslated region variant) and rs689466 (upstream transcript variant, downstream transcript variant), were genotyped using real-time Polymerase chain reaction (PCR). The linear regression models were fitted to assess the effects of the evaluated SNPs at a significance level of 5%.
resultsA total of 143 biologically unrelated patients (mean age: 13.5 ± 4.5 years) were included in the study. The F-test showed that only the regression for EARR in the mandibular molars in the dominant model for rs5275 G allele had a good fit (F = 3.50, P = 0.034). The model showed that individuals carrying at least one G allele for rs5275 had a 17% increase in EARR in the molars compared to common AA homozygotes (exp(B) = 1.17; 95% CI: 1.04, 1.32; P = 0.010). Although an effect of the G allele (rs5275) was detected, this effect did not explain much of the variability in EARR (adjusted R
conclusionThe results suggested that patients carrying the polymorphic form of the rs5275 were more likely to have EARR in the mandibular molars; therefore, COX-2 could have an effect on EARR. CLINICAL RELEVANCE: The knowledge of the genetic background concerning EARR after orthodontic treatment would aid in clinical practice to screen for associated genetic factors and potentially aid its prevention and management, considering that patients' genetic profiles would soon be available.
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