Evidence map›Paper›PMID 39617712›Full record

Trial reportJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2024

A neural regulation mechanism of head electroacupuncture on brain network of patients with stroke related sleep disorders.

Zhang Boyang, Zhou Yang, Feng Liyuan, Sui Dan, H E Lei, Tong Dan, Wang Ruoyu, Sui Xue, Song Jing, Wang Dongyan

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhang BoyangRehabilitation Department, Wuxi Hospital of Traditional Chinese Medicine, Wuxi 214000, China.
Zhou YangImaging Department, Harbin Medical University Cancer Hospital, Harbin 150000, China.
Feng LiyuanAcu-Moxi Department III, the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150000, China.
Sui DanRehabilitation Department B, Second Hospital of Harbin, Harbin 150000, China.
H E LeiAcu-Moxi Department, Lianyungang Hospital of Traditional Chinese Medicine, Lianyungang 222000,China.
Tong DanIntegrated TCM and Western Medicine Department, Suzhou Dushu lake hospital, Suzhou 215000, China.
Wang RuoyuAcu-Moxi Department III, the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150000, China.
Sui XueInternal Medicine Department, Zhaozhou Hospital of Traditional Chinese Medicine, Daqing 163000, China.
Song JingAcu-Moxi Department III, the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150000, China.
Wang DongyanAcu-Moxi Department III, the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150000, China.

Funding

Major Scientific Research Project of Wuxi Health Commission: Clinical Study of Intelligent Hand Rehabilitation Training System for Nerve Function Reconstruction of Patients with Hand Dysfunction after Cerebral Infarction Z202121National Natural Science Foundation of China Project: the Study of Central Mechanism of Electroacupuncture on Sishencong (EX-HN1) Improving Sleep Architecture and Neurocognitive Function Using Electroencephalogram-Functional Magnetic Resonance Imaging 81774426
6 · The paper itself

Abstract

objectiveTo analyze part of the mechanism of electroacupuncture on Sishencong (EX-HN1) for stroke-related sleep disorders (SSD) and post-stroke cognitive impairment (PSCI).

methodsUsing a randomized controlled trial (RCT) design, 72 patients were assigned to the electro-acupuncture (EA) group or the sham acupuncture (SA) group. A healthy control (HC) group was also included. Both groups were given routine rehabilitation treatment. Then, patients in the EA group were given additional electroacupuncture at Sishencong (EX_HN1). Meanwhile, patients in the SA group were given a flat-head needle sham/placebo treatment placed at the bilateral Jianyu (LI15) and Binao (LI14) line midpoints and the Jianyu (LI15) and Jianzhen (SI9) line midpoints. Before and after treatment, scales were collected and analyzed. In the second phase of the study, some subjects from the EA group were selected for functional magnetic resonance imaging (fMRI) data acquisition and comparative analysis with the HC group using a non-RCT design.

resultsThe EA group performed better than the SA group on the Pittsburgh sleep quality index (PSQI), Montreal cognitive assessment basic (MoCA_B), self-rating anxiety scale (SAS), and self-rating depression scale (SDS). Analysis of the fMRI showed that low-frequency (2 Hz) electroacupuncture stimulation at Sishencong (EX_HN1) can restrain frontal sup medial right (SFGmed.R), precuneus right (PCUN.R), and posterior cingulate cortex right (PCC.R) and enhance angular left (ANG.L), parietal inf left (IPL.L) and occipital mid left (MOG.L). The functional connectivity (FC) of SFGmed.R was positively correlated with PSQI. Electroacupuncture stimulation at Sishencong (EX_HN1) can reduce the side efficiency of the whole brain connection with the Thalamus.L, Hippocampus.L, and Occipital.Mid.L.

conclusionsLow frequency (2 Hz) electroacupuncture stimulation at Sishencong (EX_HN1) can simultaneously improve sleep quality, negative emotions, and cognitive functions, the first two of which may be related to SFGmed.R restraint. Electroacupuncture can make some brain areas approach the physiological bias state, which is characterized by dominant hemispheric enhancement and non-dominant hemispheric weakening. The reduced whole brain connection side efficiency with some key nodes of the brain net may relate to sleep quality improvements in SSD patients.

Indexed as

Acupuncture PointsBrainElectroacupunctureSleep Wake DisordersStrokeAdultAgedFemaleHumansMagnetic Resonance ImagingMaleMiddle Agedbrain networkelectroacupunctureneural regulationsleep disorder

Identifiers

PMID39617712
PMCPMC11589561

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.