Evidence map›Paper›PMID 39617696›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2024

Multi-omics analysis reveals the neuroprotective effect of extract against Parkinson's disease in mouse.

Kang Sohi, Lee Sueun, Moon Byeong Cheol, Song Jun Ho, Kim Sung-Ho, Moon Changjong, Lee Soong-In, Kim Chul, Kim Joong Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kang SohiDepartment of Anatomy and Convergence Medical Science, College of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea.
Lee SueunHerbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, 111, Geonjae-ro, Naju-si, Jeollanam-do 58245, Republic of Korea.
Moon Byeong CheolHerbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, 111, Geonjae-ro, Naju-si, Jeollanam-do 58245, Republic of Korea.
Song Jun HoHerbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, 111, Geonjae-ro, Naju-si, Jeollanam-do 58245, Republic of Korea.
Kim Sung-HoCollege of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea.
Moon ChangjongCollege of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea.
Lee Soong-InDepartment of Oriental Medicine Prescription, College of Oriental Medicine, Dong-Shin University, Naju-si, Jeollanam-do 58245, Republic of Korea.
Kim ChulKM Data Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Republic of Korea.
Kim Joong SunCollege of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea.

Funding

Development of Sustainable Application for Standard Herbal Resource by the Korea Institute of Oriental Medicine KSN2012320
6 · The paper itself

Abstract

objectiveTo assess

methodsExamined mRNA-DNA methylation changes induced by ARE in MPTP-induced Parkinson's disease (PD) model's substantia nigra.

resultsARE mitigated MPTP-induced motor impairment in rotarod and open field tests and preserved tyrosine hydroxylase-positive neuronal cells in substantia nigra and striatum. Genome RNA-Sequencing and Methyl-Sequencing in substantia nigra of vehicle/ARE-treated MPTP-induced PD mice showed 84 differentially expressed genes (DEGs) and 1804 differentially methylated regions (DMRs). Upregulated genes involved zinc ion homeostasis, cilium protein localization, and transcription; downregulated genes linked to ephrin receptor signaling, somitogenesis, and gene expression regulation. Hyper/hypomethylated DMRs post-ARE treatment associated with Wnt signaling, mitochondrial organization, dopamine biosynthesis, and hindbrain development. No significant correlation between DEGs and methylated genes related to PD pathogenesis.

conclusionThis research has identified the epigenetic targets of ARE's therapeutic action and gives insight on how ARE protects neurons in Parkinson's disease.

Indexed as

Mice, Inbred C57BLNeuroprotective AgentsParkinson DiseaseAnimalsDisease Models, AnimalDNA MethylationDrugs, Chinese HerbalHumansMaleMiceMultiomicsSubstantia NigraDrugs, Chinese HerbalNeuroprotective Agents1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineAtractylodis Rhizoma AlbaMethyl-seqnerve degenerationParkinson disease

Identifiers

PMID39617696
PMCPMC11589551

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.