ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2025
Neural Signatures of Cognitive Control Predict Future Adolescent Substance Use Onset and Frequency.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Developmental variation in basal ganglia tissue iron, neurocognitive functioning, and impulsivity is associated with substance use trajectories in youth.Nature communications · 2026Article
- Environmental unpredictability predicts positive social risk taking through neural cognitive control.Social cognitive and affective neuroscience · 2026Article
- Mapping EEG Metrics to Human Affective and Cognitive Models: An Interdisciplinary Scoping Review from a Cognitive Neuroscience Perspective.Biomimetics (Basel, Switzerland) · 2025Review
- Developmental variation in dopamine neurobiology, neurocognitive functioning, and impulsivity shape substance use trajectories in youth.bioRxiv : the preprint server for biology · 2025Article
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Authors and funding
6 authors.
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Abstract
backgroundAdolescent substance use is a significant predictor of future addiction and related disorders. Understanding neural mechanisms underlying substance use initiation and frequency during adolescence is critical for early prevention and intervention.
methodsThe current longitudinal study followed 91 substance-naïve adolescents annually for 7 years from ages 14 to 21 years to identify potential neural precursors that predict substance use initiation and frequency. Cognitive control processes were examined using the Multi-Source Interference Task to assess functional neural connectivity. A questionnaire was used to assess substance use frequency.
resultsStronger connectivity between the dorsal anterior cingulate cortex (dACC) and dorsolateral prefrontal cortex (dlPFC) at time 1 predicted a delayed onset of substance use, indicative of a protective effect. A notable decline in this dACC-dlPFC connectivity was observed 1 year prior to substance use initiation. Conversely, lower connectivity of the dACC with the supplementary motor area and heightened connectivity of the anterior insula with the dorsal medial prefrontal cortex and angular gyrus were predictive of greater frequency of future substance use. These findings remained after controlling for demographic and socioeconomic covariates.
conclusionsThis study highlights the critical role of cognitive control-related neural connectivity in predicting substance use initiation and frequency during adolescence. The results imply that efforts to strengthen and monitor the development of the top-down cognitive control system in the brain from early adolescence can be protective and deter progression into problematic substance use. Furthermore, for adolescents with heightened frequency of substance use, interventions may prove more effective by targeting interoceptive processes in cognitive control training.
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