Trial reportClinical and experimental dental research2024
Effects of Local and Systemic Metronidazole as Adjunctive Treatment in Chronic Periodontitis Patients.
Trial report in Clinical and experimental dental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- The Emerging Role of Hyaluronic Acid as a Multifunctional Regenerative Agent in Periodontal Healing.Gels (Basel, Switzerland) · 2026Review
- Curcumin as an adjunct in periodontal therapy: local effects, delivery systems, and clinical perspectives.Frontiers in dental medicine · 2026Review
- Effects of Nd∶YAP laser-assisted periodontal therapy on masticatory function and gingival circulation indices in patients with chronic periodontitis.Lasers in medical science · 2025Article
- Curcumin-loaded Nanofibers versus Metronidazole Gel in the Treatment of Chronic Periodontitis: A Double-blind, Randomized Controlled Trial.Journal of pharmacy & bioallied sciences · 2025Article
- Locally delivered 1% metformin gel improves periodontal parameters: A systematic review and meta-analysis.The Saudi dental journal · 2025Review
- Review
- Dual-action platelet-rich fibrin in periodontal therapy: Assessing the efficacy of injectable versus metronidazole-enhanced platelet-rich fibrin in non-surgical periodontal treatment - A clinical study.Journal of oral biology and craniofacial researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectivesThis study aimed to compare the effects of local and systemic metronidazole in patients with chronic periodontitis. MATERIALS AND
methodsIn this randomized clinical study, 30 patients (3 teeth per patient) were treated in three groups: scaling and root planing (SRP) treatment alone, metronidazole tablet as adjunctive treatment, and metronidazole gel as adjunctive treatment. BOP (bleeding on probing), PPD (pocket probing depth), and CAL (clinical attachment level) data were collected at the beginning and 3 months later. Collected data were tested by Wilcoxon and Kruskal-Wallis tests.
resultsBOP, CAL, and PPD levels were significantly different at the beginning of treatment and after 3 months, and this was true for all treatments. BOP, CAL, and PPD levels did not differ significantly between the three groups after the treatment (p > 0.05).
conclusionThe effectiveness of these methods was all equal and SRP is still considered as the gold standard in the treatment of periodontal diseases. Further studies are needed to confirm the findings. Chronic periodontitis is a progressive disease that can cause tooth loss. The accepted treatment is SRP. Antibiotics used systemically can penetrate the depth of the periodontal pockets but have several side effects. Hence, using a less complicated medicinal form as a topical gel as adjunctive therapy in treating chronic periodontitis can be more effective.
trial registrationIranian clinical trial https://en.irct.ir/: IRCT20210408050898N1.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.