ArticleNeuroradiology2024
Disturbed neurovascular coupling in patients with white matter hyperintensities: potential biomarker for cognitive impairment.
Article in Neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Chronic Aerobic Exercise Alleviates Amyloid-induced Capillary Dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Inflammaging and neurovascular unit dysfunction in cognitive ageing: mechanisms, biomarkers, and therapeutic opportunities.Frontiers in aging neuroscience · 2026Review
- Preserved neurovascular coupling in early multiple sclerosis is associated with reduced white matter lesion burden.Therapeutic advances in neurological disorders · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
purposeTo explore the neurovascular mechanisms of white matter hyperintensities (WMHs)-related cognitive impairment by introducing a neurovascular biomarker, neurovascular coupling (NVC).
methodsWe applied resting-state functional magnetic resonance imaging combined with arterial spin labeling to investigate the NVC dysfunctional patterns in patients with pure WMHs. Partial correlation, mediation, and exploratory subgroup analyses were adopted to explore the relationship among WMHs, NVC dysfunction, and cognitive decline.
resultsWe found 21 brain regions with NVC dysfunction in patients with pure WMHs, mainly distributed in the default mode network, dorsal attention network, subcortical nucleus, and limbic system (p < 0.0125, Bonferroni correction). The NVC dysfunction of brain regions in the subcortical nucleus and limbic system correlated with the total WMHs burden and paraventricular WMHs burden (q < 0.05, FDR correction). The reduced NVC of the left amygdala partially mediated the impact of paraventricular WMHs on executive function (Mediation effect: -0.117; 95%CI: -4.042,-0.011; p < 0.05). Among the WMHs subjects without cognitive impairment, the increased NVC of the left basal ganglia significantly correlated with the MoCA score (r = 0.539, p < 0.05).
conclusionThese findings reveal an underlying neurovascular mechanism of WMHs-related cognitive impairment. The neurovascular functions of the left amygdala and left basal ganglia may involve cognitive damage and compensation, respectively, and can be used as potential biomarkers and therapeutic targets for cognitive impairment in patients with WMHs.
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