ArticleCommunications biology2024
Reconfiguration of metabolic connectivity in ageing.
Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Individual-level metabolic connectivity captures cortical morphology and their coupling strengthens in the ageing brain.European journal of nuclear medicine and molecular imaging · 2026Article
- Human cerebral cortex organization characterized by functional PET-FDG "Metabolic Connectivity".European journal of nuclear medicine and molecular imaging · 2026Article
- Brain maintenance biomarkers from structural and functional interactions in aging and neurodegeneration.Nature communications · 2026Article
- Individual-level metabolic connectivity captures cortical morphology and their coupling strengthens with age.bioRxiv : the preprint server for biology · 2026Article
- Human Cerebral Cortex Organization Characterized by Functional PET-FDG "Metabolic Connectivity".bioRxiv : the preprint server for biology · 2026Article
- Brain glucodynamic variability is an essential feature of the metabolism-cognition relationship.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Intermittent fasting and neuroprotection in Alzheimer's disease: metabolic mechanisms, cellular signaling, and brain-peripheral crosstalk.Frontiers in nutrition · 2026Review
- Spatially convergent functional MRI signatures of diabetes and male sex identify genetic vulnerabilities to accelerated brain ageing.Brain communications · 2026Article
- MEG state dynamics of sentence generation: evidence for a compensatory segmentation mechanism in healthy aging.Frontiers in computational neuroscience · 2026Article
- The metabolic engine of cognition: microglia-neuron interactions in health, ageing and disease.Nature metabolism · 2025Review
- Age-Related Changes in Caudate Glucose Metabolism: Insights from Normative Modeling Study in Healthy Subjects.Metabolites · 2025Article
- Lifespan oscillatory dynamics in lexical production: A population-based MEG resting-state analysis.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Metabolic connectivity has greater predictive utility for age and cognition than functional connectivity.Brain communications · 2025Article
- Stable brain PET metabolic networks using a multiple sampling scheme.Network neuroscience (Cambridge, Mass.) · 2025Article
- Glucose metabolism echoes long-range temporal correlations in the human brain.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
9 authors.
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Abstract
Information transfer across the brain has a high energetic cost and requires efficient glucose metabolism. Here we use recently developed high temporal resolution functional positron emission tomography (fPET) to create a timecourse of glucose metabolism for individual subjects and assess the relationship between metabolic connectivity and cognitive function in ageing. The metabolic connectomes of 40 younger (mean 27.9 years; range 20-42) and 46 older (mean 75.8; 60-89) adults were characterised by high connectivity in the frontal, temporal, motor, parietal and medial cortices. Older age was associated with lower global integration of metabolic hub regions. In younger adults, a high proportion of glucose was used to support hubs in the frontal regions. Older adults used a higher proportion of a smaller energy budget to support mostly posterior hub regions. This metabolic network topology of older adults was associated with worse cognitive performance. We conclude that ageing is associated with a high glucose cost in hub regions and disrupted information transfer across the metabolic network. Our results highlight the fundamental role that metabolism plays in supporting information transfer in the brain and the unique insights that metabolic connectivity provides into the ageing brain.
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