Evidence map›Paper›PMID 39616239›Full record

ArticlePediatric research2025

Comparison of nasal microbiota between preterm and full-term infants in early life.

Olga Gorlanova, Annika Nissen-Kratzert, Nadja Mostacci, Céline Rüttimann, Noemi Künstle, Andrea Marten, Amanda Gisler, Katharina Bacher, Fabienne Decrue, Yasmin Salem and 11 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Olga Gorlanova *University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Annika Nissen-Kratzert *University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Nadja MostacciInstitute for Infectious Diseases, University of Bern, Bern, Switzerland.
Céline RüttimannUniversity Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Noemi KünstleUniversity Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Andrea MartenUniversity Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Amanda GislerUniversity Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Katharina BacherInstitute for Infectious Diseases, University of Bern, Bern, Switzerland.
Fabienne DecrueUniversity Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Yasmin SalemUniversity Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Jakob UsemannUniversity Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Insa KortenDivision of Pediatric Respiratory Medicine and Allergology, Department of Pediatrics, University Hospital Bern, University of Bern, Bern, Switzerland.
Sophie YammineDivision of Pediatric Respiratory Medicine and Allergology, Department of Pediatrics, University Hospital Bern, University of Bern, Bern, Switzerland.
Uri NahumUniversity Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Sven SchulzkeUniversity Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Philipp LatzinUniversity Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland.
Martin RöösliSwiss Tropical and Public Health Institute Basel, Allschwil, Switzerland.
Oliver FuchsDivision of Pediatric Respiratory Medicine and Allergology, Department of Pediatrics, University Hospital Bern, University of Bern, Bern, Switzerland.
BILD study consortium
Markus Hilty *Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
Urs Frey *University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland. urs.frey@ukbb.ch.ORCID http://orcid.org/0000-0003-3773-2822

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe respiratory microbiota influences infant immune system maturation. Little is known about how perinatal, physiological, and environmental exposures impact the nasal microbiota in preterm infants after discharge, or nasal microbiota differences between preterm and healthy full-term infants.

methodsNasal swabs (from 136 preterm and 299 full-term infants at mean postmenstrual age of 45 weeks from the prospective Basel-Bern Infant Lung Development cohort) were analyzed by 16S-rRNA gene amplification and sequencing (Illumina MiSeq). Associations were tested with multivariable linear regression and principal coordinate analysis.

resultsPresence of older siblings in preterm infants was associated with β-diversity (PERMANOVA p = 0.001) and an increased abundance of Moraxella and Haemophilus. The nasal microbiota of preterm infants exhibited a distinct composition compared to that of full-term infants (PERMANOVA, R

conclusionOur results indicate that, despite both infant groups having similar nasal microbiota patterns, there are some disparities which suggest that prematurity influences the initial microbiota colonization. In preterm infants the presence of older siblings had an effect on the nasal microbiota, whereas perinatal and early postnatal factors did not show significant effects. IMPACT: Presence of older siblings affected the nasal microbiota of preterm infants. This study demonstrated that microbiota composition differs between full-term and preterm infants, with a lower abundance of Moraxella and Dolosigranulum in preterm infants. Examining the differences in nasal microbiota between preterm and full-term infants may contribute to understanding the trajectory of the bacterial component of the nasal microbiota of preterm infants.

Indexed as

Infant, PrematureMicrobiotaNoseFemaleGestational AgeHumansInfantInfant, NewbornMaleMoraxellaProspective StudiesRNA, Ribosomal, 16SSiblingsRNA, Ribosomal, 16S

Identifiers

PMID39616239
PMCPMC12454110

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.