ArticleNature communications2024
Subtilase SBT5.2 inactivates flagellin immunogenicity in the plant apoplast.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- NbRD21 protease controls receptor kinase homeostasis in Nicotiana benthamiana.The New phytologist · 2026Article
- Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026Review
- Processing and release of the maize phytocytokine Zip1.Plant physiology · 2026Article
- Diverse phytocytokines derived from conserved subtilase scaffolds co-evolved with clustered receptors to confer defence responses in legumes.Nature plants · 2026Article
- Natural Variation of NAR5 Determines Nitrogenase Activity and the Yield in Soybean.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Phytosulfokine signaling module activates the Nod factor receptor to control soybean nodulation.Nature communications · 2026Article
- A secreted citrus protease cleaves an outer membrane protein of the Huanglongbing pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Plant subtilases as key initiators of peptide ligand-receptor signaling.The Plant journal : for cell and molecular biology · 2026Review
- Specialization of independently acquired flagellar FliC proteins in plant-associatedProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Specialization of independently acquired flagellar FliC proteins in plant-associatedbioRxiv : the preprint server for biology · 2026Article
- The size of apoplastic peptides: Do the cell wall matrix and cell-surface receptors matter?Plant communications · 2026Article
- Hacking the immune system: plant immune protease engineering for crop protection.Journal of experimental botany · 2025Review
- Four guidelines to identify bona fide protease-substrate pairs.Journal of experimental botany · 2025Review
- An apoplastic fungal effector disrupts N-glycosylation of ZmLecRK1, inducing its degradation to suppress disease resistance in maize.Nature plants · 2025Article
- mamp-ml: A deep learning approach to epitope immunogenicity in plants.bioRxiv : the preprint server for biology · 2025Article
- Flagellin sensing, signaling, and immune responses in plants.Plant communications · 2025Review
- Plant Pattern recognition receptors: Exploring their evolution, diversification, and spatiotemporal regulation.Current opinion in plant biology · 2024Article
- Extracellular plant subtilases dampen cold-shock peptide elicitor levels.Nature plants · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Most angiosperm plants recognise the 22-residue flagellin (flg22) epitope in bacterial flagellin via homologs of cell surface receptor FLS2 (flagellin sensitive-2) and mount pattern-triggered immune responses. However, flg22 is buried within the flagellin protein indicating that proteases might be required for flg22 release. Here, we demonstrate the extracellular subtilase SBT5.2 not only releases flg22, but also inactivates the immunogenicity of flagellin and flg22 by cleaving within the flg22 epitope, consistent with previous reports that flg22 is unstable in the apoplast. The prolonged lifetime of flg22 in sbt5.2 mutant plants results in increased bacterial immunity in priming assays, indicating that SBT5.2 counterbalances flagellin immunogenicity to provide spatial-temporal control and restrict costly immune responses and that bacteria take advantage of the host proteolytic machinery to avoid detection by flagellin having a protease-sensitive flg22 epitope.
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Registered trials
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