ArticleNature communications2024
Enantioselective construction of C-B axially chiral alkenylborons by nickel-catalyzed radical relayed reductive coupling.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Enantioselective Vinyl Radical Addition to Aldehydes via Dual Chromium Catalysis.Angewandte Chemie (International ed. in English) · 2026Article
- Copper-Catalyzed Asymmetric Hydroboration of Alkynes to C-N Axially Chiral Azaborines via Dynamic Kinetic Resolution.Angewandte Chemie (International ed. in English) · 2026Article
- Nickel-Catalyzed Boron-Mediated Saturative Trifunctionalization of Alkynes.Angewandte Chemie (International ed. in English) · 2026Article
- The acylative kinetic resolution of 1,2-azaborine naphthols.Chemical science · 2026Article
- Stereogenic S‑Induced Generation of Axially Chiral Cyclic Vinyl Sulfinamides and Serendipitous Diastereomeric Enrichment.JACS Au · 2026Article
- Catalytic asymmetric construction of remote P or other heteroatom (Si/S) stereogenic axially chiral scaffolds.Chemical science · 2026Article
- Transition-metal-catalyzed C-S bond formation: recent developments and pharmaceutical applications.Frontiers in chemistry · 2026Review
- Rhodium-catalyzed construction of boron-based point and axial chirality via asymmetric annulation of alkynylborons.Nature communications · 2025Article
- Regioselective Multiboration and Hydroboration of Alkenes and Alkynes Enabled by a Platinum Single-Atom Catalyst.ACS catalysis · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The catalytic asymmetric synthesis of axially chiral alkenes remains a daunting challenge due to the lower rotational barrier, especially for longer stereogenic axis (e.g. C-B axis). The asymmetric radical difunctionalization of alkynes represents an efficient strategy for these targets. Key to the success of such transformations lies in aryl-stabilized highly reactive alkenyl radical intermediates, however, it remains an elusive whether a boryl group could play a similar role. Here we report a nickel-catalyzed atroposelective radical relayed reductive coupling reaction of our designed ethynyl-azaborines with simple alkyl and aryl halides through a boron-stabilized vinyl radical intermediate. This transformation enables a straightforward access to the challenging axially chiral alkenylborons bearing a C-B axis in generally high enantioselectivity and excellent stereoselectivity.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.