Evidence map›Paper›PMID 39615812›Full record

ArticleThe journal of pain2025

Elevated posterior insula glutamate in patients with sickle cell disease.

Xiaopeng Zhou, Eric Ichesco, Andrew Q Pucka, Ziyue Liu, Andrew Rw O'Brien, Steven E Harte, Richard E Harris, Ying Wang

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05045820 naactive not recruitingnot on this map

Integrative Medicine in Pain Management in Sickle Cell Disease: Assessing the Clinical Efficacy and Neurobiological Impact With Acupuncture

TypeinterventionalSponsorIndiana UniversityRan2021 to 2026Enrolled106ConditionsSickle Cell Disease, Pain, Acupuncture, Quantitative Sensory TestingArmsneedling acupuncture, laser acupuncture
NCT06725550 narecruitingnot on this mapstarted 2026, after this paper: background citation

Integrative Medicine in Pain Management in Sickle Cell Disease: Assessing the Clinical Efficacy and Neurobiological Impact With Acupuncture, 2.0

TypeinterventionalSponsorUniversity of CincinnatiRan2026 to 2031Enrolled120ConditionsSickle Cell Disease, Pain, Acupuncture, Quantitative Sensory TestingArmsneedling acupuncture, laser acupuncture
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaopeng ZhouSchool of Health Sciences, Purdue University, West Lafayette, IN, USA.
Eric IchescoDepartment of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, USA.
Andrew Q PuckaDepartment of Anesthesia, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Ziyue LiuDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA.
Andrew Rw O'BrienDivision of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Steven E HarteDepartment of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, USA.
Richard E HarrisDepartment of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, USA; Susan Samueli Integrative Health Institute, School of Medicine, University of California at Irvine, Irvine, CA, USA; Department of Anesthesiology and Perioperative Care, School of Medicine, University of California at Irvine, Irvine, CA, USA.
Ying WangDepartment of Anesthesia, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA; Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: ywa12@iu.edu.

Funding

Integrative Medicine for Pain Management in Sickle Cell DiseaseR00AT010012 · NCCIH · INDIANA UNIVERSITY INDIANAPOLIS · PI WANG, YING · 2021 to 2023
$735k
NCCIH NIH HHS R00 AT010012
6 · The paper itself

Abstract

Sickle cell disease (SCD) is an inherited hemolytic disorder accompanied by chronic pain and recurrent acute painful episodes known as vaso-occlusive crises (VOCs). Increased Glx (glutamate+glutamine) and lowered GABA concentration have been reported in the insula of patients with fibromyalgia, a nociplastic chronic pain condition, and may affect the pathophysiology of pain-related syndromes.Therefore, proton magnetic resonance spectroscopy (

Indexed as

Anemia, Sickle CellGlutamic AcidInsular CortexAdultFemaleGlutamineHumansMaleMiddle AgedProton Magnetic Resonance SpectroscopyYoung AdultGlutamic AcidGlutamine(1)H-MRSBrain metabolitesGlutamatePainSickle cell diseaseVaso-occlusive crisis

Identifiers

PMID39615812
PMCPMC11807739

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.