ArticleAmerican journal of preventive medicine2025
Cost-Effectiveness and Public Health Impact of 24-Valent Pneumococcal Conjugate Vaccine Compared With the Recommended Pneumococcal Vaccines in Older Adults.
Article in American journal of preventive medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Use of Health State Utility Values in Cost-Utility Analyses of Selected Infectious Diseases in Aging Populations: A Systematic Review and Critical Appraisal.PharmacoEconomics - open · 2026Pooled it
- Impact of Serotype Uncertainty on Adult Pneumococcal Vaccine Options: A Value of Information Analysis.American journal of preventive medicine · 2026Article
- Future Pneumococcal Vaccines: Shifting from Capsular Polysaccharides to Protein-Based Immunogens.Vaccines · 2026Review
- Public health effects of adult pneumococcal vaccination choice amid increased serotype 4 rates in US subpopulations.Public health · 2025Article
- Cost-effectiveness and budget impact analyses of the 24-valent pneumococcal conjugate vaccine in adults aged 50 and older.Vaccine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
introductionThe potential impact of an in-development 24-valent pneumococcal conjugate vaccine compared with that of currently recommended vaccines in older adults is unclear. Similar to most currently available pneumococcal conjugate vaccines, 24-valent pneumococcal conjugate vaccine's formulation is based on childhood pneumococcal disease epidemiology. Decision analysis techniques were used to estimate 24-valent pneumococcal conjugate vaccine cost-effectiveness and public health effects in U.S. older adults.
methodsA Markov model compared 24-valent pneumococcal conjugate vaccine with currently recommended U.S. pneumococcal vaccination strategies in older adults (aged ≥65 years) and with no vaccination. Age-, race-, and chronic medical condition-specific pneumococcal illness risks and serotype-specific disease risks were obtained from Centers for Disease Control and Prevention data. Vaccine effectiveness was estimated using Delphi panel and clinical trial data. Vaccination and pneumococcal illness costs were from U.S. DATABASES: Scenario analyses examined indirect effects of childhood pneumococcal vaccination on adult disease. Data were collected and analyses were performed in 2024.
resultsThe 24-valent pneumococcal conjugate vaccine prevented fewer pneumococcal disease cases and deaths than the recently recommended 21-valent pneumococcal conjugate vaccine, which is formulated on the basis of adult pneumococcal disease serotypes. In cost-effectiveness analyses, 21-valent pneumococcal conjugate vaccine was economically favorable compared with 24-valent pneumococcal conjugate vaccine and all other vaccination strategies, both without and with consideration of potential childhood vaccination indirect effects. These findings were robust and consistent with those in deterministic and probabilistic sensitivity analyses.
conclusionsIn older adults, 24-valent pneumococcal conjugate vaccine was clinically and economically unfavorable compared with 21-valent pneumococcal conjugate vaccine, which covers more adult disease-causing pneumococcal serotypes and is less susceptible to childhood vaccination indirect effects.
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