Evidence map›Paper›PMID 39615581›Full record

ArticleNeuroscience letters2025

Sex related differences in cognitive deficits: Disrupted Arc/Arg3.1 signaling in an HIV model.

Yun-Kyung Hahn, Sara R Nass, William D Marks, Jason J Paris, Kurt F Hauser, Pamela E Knapp

Abstract read
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In one paragraph

Article in Neuroscience letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yun-Kyung HahnDepartment of Anatomy and Neurobiology, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298-0709, USA.
Sara R NassDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, School of Medicine, P.O. Box 980613, Richmond, VA 23298-0613, USA.
William D MarksDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, School of Medicine, P.O. Box 980613, Richmond, VA 23298-0613, USA.
Jason J ParisDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, School of Medicine, P.O. Box 980613, Richmond, VA 23298-0613, USA.
Kurt F HauserDepartment of Anatomy and Neurobiology, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298-0709, USA; Department of Pharmacology and Toxicology, Virginia Commonwealth University, School of Medicine, P.O. Box 980613, Richmond, VA 23298-0613, USA; Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Medical College of Virginia (MCV) Campus, P.O. Box 980059, Richmond, VA 23298-0059, USA.
Pamela E KnappDepartment of Anatomy and Neurobiology, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298-0709, USA; Department of Pharmacology and Toxicology, Virginia Commonwealth University, School of Medicine, P.O. Box 980613, Richmond, VA 23298-0613, USA; Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Medical College of Virginia (MCV) Campus, P.O. Box 980059, Richmond, VA 23298-0059, USA. Electronic address: pamela.knapp@vcuhealth.org.

Funding

MOR and CCR5 interactive signaling mediates opiate and HIV-driven synaptodendritic injuryR01DA034231 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HAUSER, KURT F, KNAPP, PAMELA E · 2013 to 2023
$5.4M
Innovative therapeutic approaches to address excitotoxic CNS/neuronal damage in opioid-neuroHIV comorbidityR01DA057346 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Kurt F Hauser, Pamela E Knapp · 2022 to 2026
$3.4M
pTau-related neuron and cognitive dysfunction in opioid-HIV comorbidity: Longitudinal and functional studiesR01DA060762 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Kurt F Hauser, Pamela E Knapp · 2024 to 2026
$2.1M
NIDA NIH HHS R01 DA034231NIDA NIH HHS R01 DA057346NIDA NIH HHS R01 DA060762
6 · The paper itself

Abstract

Combined and highly active anti-retroviral therapies (cART) have transitioned HIV into a more chronic disease. Roughly half of people living with HIV (PLWH) still experience neurocognitive disorders, albeit less severely than in the pre-cART era. Sex-related effects on memory/cognition remain understudied, although the percentage of PLWH that are female has increased. We utilized a transgenic mouse model of HIV that conditionally expresses HIV-1 Tat

Indexed as

Cognitive DysfunctionCytoskeletal ProteinsHippocampusHIV InfectionsMice, TransgenicNerve Tissue ProteinsSignal TransductionAnimalsDisease Models, AnimalFemaleHumansMaleMemoryMiceSex Characteristicstat Gene Products, Human Immunodeficiency Virusactivity regulated cytoskeletal-associated proteinCytoskeletal ProteinsNerve Tissue Proteinstat Gene Products, Human Immunodeficiency VirusActivity-regulated cytoskeleton-associated proteinAmyloid βArg3.1Cognitive deficitsCREBcyclic AMP response element binding proteinHIV-associate neurocognitive deficits (HAND)

Identifiers

PMID39615581
PMCPMC11707792

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.