Evidence map›Paper›PMID 39615218›Full record

ReviewTransplantation reviews (Orlando, Fla.)2025

Complement and T cell activation in transplantation.

Sara Alibrandi, Angela Clemens, Nicholas Chun

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Transplantation reviews (Orlando, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sara AlibrandiTranslational Transplant Research Center and Barbara T. Murphy Division of Nephrology, Icahn School of Medicine at Mount Sinai, NY, NY, USA; Department of Medicine and Surgery, University of Parma, Parma, Italy; Nephrology Unit, University Hospital of Parma, Parma, Italy.
Angela ClemensTranslational Transplant Research Center and Barbara T. Murphy Division of Nephrology, Icahn School of Medicine at Mount Sinai, NY, NY, USA.
Nicholas ChunTranslational Transplant Research Center and Barbara T. Murphy Division of Nephrology, Icahn School of Medicine at Mount Sinai, NY, NY, USA. Electronic address: Nicholas.Chun@mssm.edu.

Funding

Complement-Mediated Exosome Function in TransplantationR01AI172899 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Nicholas Chun · 2022 to 2026
$2.7M
NIAID NIH HHS R01 AI172899
6 · The paper itself

Abstract

The complement system plays a critical role in modulating adaptive T cell responses. Coordination of the proinflammatory signaling cascade and complement regulators permits efficient T cell priming and survival, while minimizing off-target damage to healthy host cells. In the context of transplantation, anti-donor T cell immunity remains a barrier to long term graft health and complement-targeted therapies have shown the potential to significantly improve patient outcomes. Here we will review our current understanding of complement-mediated T cell function and how these findings may be harnessed in organ transplantation.

Indexed as

Complement ActivationComplement System ProteinsLymphocyte ActivationOrgan TransplantationT-LymphocytesGraft RejectionGraft SurvivalHumansComplement System ProteinsAdaptive immunityComplement systemComplosomeT cell activationTransplantation

Identifiers

PMID39615218
PMCPMC11710966

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.