Evidence map›Paper›PMID 39615160›Full record

ArticleThe Journal of surgical research2025

Colorectal Surgery Outcomes and Healthcare Burden for Medicare Beneficiaries With Dementia.

Clancy J Clark, Rachel Adler, Lingwei Xiang, Samir K Shah, Zara Cooper, Dae Hyun Kim, Kueiyu Joshua Lin, John Hsu, Stuart Lipsitz, Joel S Weissman

Abstract read
In one paragraph

Article in The Journal of surgical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Clinical outcomes following elective lumbar spine surgery in patients living with dementia.The spine journal : official journal of the North American Spine Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Clancy J ClarkDivision of Surgical Oncology, Department of General Surgery, Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina. Electronic address: cjclark@wakehealth.edu.
Rachel AdlerCenter for Surgery and Public Health, Brigham and Women's Hospital, Boston, Massachusetts.
Lingwei XiangCenter for Surgery and Public Health, Brigham and Women's Hospital, Boston, Massachusetts.
Samir K ShahDivision of Vascular Surgery, Department of General Surgery, University of Florida, Gainesville, Florida.
Zara CooperCenter for Surgery and Public Health, Brigham and Women's Hospital, Boston, Massachusetts.
Dae Hyun KimHinda and Arthur Marcus Institute for Aging Research, Hebrew Senior Life, Harvard Medical School, Boston, Massachusetts.
Kueiyu Joshua LinDivision of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
John HsuMongan Institute, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts.
Stuart LipsitzCenter for Surgery and Public Health, Brigham and Women's Hospital, Boston, Massachusetts.
Joel S WeissmanCenter for Surgery and Public Health, Brigham and Women's Hospital, Boston, Massachusetts.

Funding

Tradeoffs in the Design of Public Long-Term Care BenefitsP01AG032952 · NIA · HARVARD MEDICAL SCHOOL · PI Bruce E. Landon · 2009 to 2026
$39.0M
COVID-19 and Acute Medical Care: Impact on Dementia PatientsR01AG062282 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HSU, JOHN · 2018 to 2022
$4.5M
Understanding and Improving Surgical Decision-Making for Persons Living with Dementia, their Family Caregivers, and their Providers: A Mixed Methods StudyR01AG067507 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISSMAN, JOEL S. · 2020 to 2024
$4.4M
Impact of the COVID-19 Pandemic on Patients with Alzheimer's Disease and Alzheimer's Disease Related DementiasU01AG076478 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HSU, JOHN · 2021 to 2025
$4.1M
Impact of Medicare Polices on Beneficiaries with ADRDRF1AG083033 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI JOHN HSU, SHARON-LISE Teresa NORMAND · 2023 to 2026
$4.1M
Applications of Claims-Based Frailty Index to Advance Evidence for Frailty-Guided Decision-Making - Extension to ADRDR01AG071809 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI KIM, DAE HYUN · 2021 to 2025
$3.5M
Prospective Monitoring of Newly Approved Cardiovascular Drugs in Older Adults with FrailtyR01AG062713 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI KIM, DAE HYUN · 2019 to 2022
$2.8M
Epidemiology and Risk of Antipsychotic Use in Hospitalized Elderly with DeliriumR01AG056368 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI KIM, DAE HYUN · 2018 to 2020
$1.8M
Mid-Career Mentoring Award For Patient-Oriented Research in Frailty and Health OutcomesK24AG073527 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI Dae Hyun Kim · 2022 to 2026
$862k
Restricted Mean Survival Time to Interpret Clinical Trials for Treatment Decision-Making in Older AdultsR21AG060227 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI KIM, DAE HYUN · 2019 to 2020
$449k
NIA NIH HHS K24 AG073527NIA NIH HHS P01 AG032952NIA NIH HHS R01 AG056368NIA NIH HHS R01 AG062282NIA NIH HHS R01 AG062713NIA NIH HHS R01 AG067507NIA NIH HHS R01 AG071809NIA NIH HHS R21 AG060227NIA NIH HHS RF1 AG083033NIA NIH HHS U01 AG076478
6 · The paper itself

Abstract

introductionPatients with Alzheimer's disease and related dementias (ADRD) undergoing colorectal surgery have suboptimal postoperative outcomes, but the specific adverse outcomes and the context of these worse outcomes on a national level are not well understood.

methodsColorectal surgery patients with and without ADRD from January 1, 2017, to October 1, 2018, were identified using traditional, fee-for-service Medicare claims data. Unadjusted and adjusted analyses were performed to evaluate postoperative outcomes.

results123,324 Medicare beneficiaries (mean age 76.5, 59.3% female) underwent colorectal surgery in the study cohort with 8.3% (n = 10,254) having a preoperative diagnosis of ADRD. Colorectal surgery patients with ADRD were older (81 versus 76 y old, P < 0.001), frail (42.8% versus 13.6%, P < 0.001), and had more comorbidities (Elixhauser Score 19.6 versus 13.9, P < 0.001) compared with those without an ADRD diagnosis. Patients with ADRD more often had open surgery (75.2% versus 65.7%, P < 0.001) and emergency surgery (65.1% versus 37.8%, P < 0.001). Unadjusted and adjusted analyses demonstrated that patients with ADRD have an increased risk of in-hospital, 30-d, and 90-day mortality, as well as postoperative complications. Patients with ADRD required more healthcare resources after colorectal surgery including increased length of stay (7 versus 5 days), discharge to a higher level of care (60.8% versus 25.8%, P < 0.001), and discharge to a facility (54.0% versus 23.8%, P < 0.001).

conclusionsFor patients undergoing colorectal surgery, the diagnosis of ADRD is an independent risk factor for adverse postoperative outcomes and results in increased healthcare resource utilization both in hospital and after discharge.

Indexed as

Alzheimer DiseaseColorectal SurgeryDementiaPostoperative ComplicationsAgedAged, 80 and overFemaleHumansLength of StayMaleMedicareRetrospective StudiesTreatment OutcomeUnited StatesAlzheimer's diseaseColectomyDementiaProctectomyTotal abdominal colectomy

Identifiers

PMID39615160
PMCPMC11779580

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.