Evidence map›Paper›PMID 39614957›Full record

SynthesisHead and neck pathology2024

Clinicopathological, Prognostic and Molecular Profile of Salivary Gland Intraductal Carcinoma: A Systematic Review.

João Paulo Gonçalves de Paiva, Daniela Giraldo Roldán, Éder Gerardo Santos Leite, Maíra Medeiros Pacheco de Andrade, Alan Roger Santos-Silva, Alexandre de Oliveira Sales, Ciro Dantas Soares, Jacks Jorge

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Head and neck pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

João Paulo Gonçalves de PaivaOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Piracicaba, São Paulo, 13414-903, Brazil. joaopaulogoncalvesdepaiva@gmail.com.ORCID http://orcid.org/0000-0002-0079-2373
Daniela Giraldo RoldánOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Piracicaba, São Paulo, 13414-903, Brazil.ORCID http://orcid.org/0000-0001-7150-3025
Éder Gerardo Santos LeiteOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Piracicaba, São Paulo, 13414-903, Brazil.ORCID http://orcid.org/0000-0002-8642-3834
Maíra Medeiros Pacheco de AndradePrivate Pathology Service, Getúlio Sales Diagnósticos, GSD, Natal, Rio Grande Do Norte, Brazil.ORCID http://orcid.org/0000-0002-1830-8439
Alan Roger Santos-SilvaOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Piracicaba, São Paulo, 13414-903, Brazil.ORCID http://orcid.org/0000-0003-2040-6617
Alexandre de Oliveira SalesPrivate Pathology Service, Getúlio Sales Diagnósticos, GSD, Natal, Rio Grande Do Norte, Brazil.
Ciro Dantas SoaresOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Piracicaba, São Paulo, 13414-903, Brazil.ORCID http://orcid.org/0000-0002-6861-6640
Jacks JorgeOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Piracicaba, São Paulo, 13414-903, Brazil.ORCID http://orcid.org/0000-0001-8808-8104

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001
6 · The paper itself

Abstract

purposeThis study aimed to conduct a systematic review summarizing the clinicopathological, prognostic, and molecular features of salivary gland intraductal carcinoma (SGIC).

methodsThis study followed the PRISMA 2020 guidelines and was registered in the PROSPERO database. It included case reports, case series studies, and cohort studies of SGIC indexed in the PubMed, Web of Science, Scopus, and Embase databases published between 1983 and 2024. Collected variables underwent descriptive analysis, association analysis using Fisher's tests, and Kaplan-Meier analysis. The quality assessment of the included studies was conducted using the Joanna Briggs Institute tools.

resultsThis systematic review yielded 59 studies, comprising 186 SGIC cases. Most of cases involved the parotid gland of male patients around 60 years old. Lesions predominantly exhibited noninvasive growth, an intercalated duct phenotype, and minimal pleomorphism. Most of the patients did not develop recurrent or metastatic disease, indicating a good prognosis. However, male sex, invasive lesions, adjuvant treatments, high-grade lesions, as well as lymph node or distant metastasis negatively affected the survival rates. Overall SGIC cases showed S100, mammaglobin, SOX10, AR, CK7, p63, calponin, CK14, SMA, and p40 positivity and a low Ki67 index. Common molecular alterations included NCOA4-RET, TRIM33-RET, and TRIM27-RET fusions, and HRAS, PIK3CA, and BRAF V600E mutations.

conclusionSGIC is a histopathologically and molecularly heterogeneous lesion with an overall excellent prognosis. The presence of invasive lesions, as well as lymph node or distant metastasis, has emerged as one of the most critical prognostic factors in SGIC patients.

Indexed as

Salivary Gland NeoplasmsBiomarkers, TumorCarcinoma, Intraductal, NoninfiltratingFemaleHumansMaleMiddle AgedPrognosisBiomarkers, TumorHead and neck neoplasmsIntraductal carcinomaSalivary gland neoplasmsSalivary glands

Identifiers

PMID39614957
PMCPMC11608184

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.