Evidence map›Paper›PMID 39614954›Full record

ArticleMolecular diversity2025

A multitask interpretable model with graph attention mechanism for activity prediction of low-data PIM inhibitors.

Zixiao Wang, Lili Sun, Yu Chang, Fang Yang, Kai Jiang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zixiao Wang *Department of Pharmacy, Honghui Hospital, Xi' an Jiaotong University, Xi' an, 710054, China. zixiaowang1112@foxmail.com.
Lili Sun *Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Yu ChangDepartment of Pharmacy, Honghui Hospital, Xi' an Jiaotong University, Xi' an, 710054, China.
Fang YangDepartment of Pharmacy, Honghui Hospital, Xi' an Jiaotong University, Xi' an, 710054, China.
Kai JiangDepartment of Pharmacy, Honghui Hospital, Xi' an Jiaotong University, Xi' an, 710054, China. jiangkai5599@163.com.

Funding

The First Affiliated Hospital of Xi'an Jiaotong University PT002191
6 · The paper itself

Abstract

The aberrant expression of proviral integration site for Moloney murine leukemia virus (PIM) kinases is closely related to various tumors and chemotherapy resistance, making them attractive targets for cancer therapy. However, due to the extremely high homology among the three PIM isoforms (PIM1, PIM2, PIM3) and the limited availability of existing bioactivity data, screening and designing selective PIM inhibitors remain a daunting challenge. To address this issue, this study constructed a multitask regression model that can simultaneously predict the half-maximal inhibitory concentration (IC

Indexed as

Protein Kinase InhibitorsProto-Oncogene Proteins c-pim-1HumansProtein Kinase InhibitorsProto-Oncogene Proteins c-pim-1proto-oncogene proteins pimGraph Attention MechanismMultitask interpretable modelPIM inhibitorsTransfer learning

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.