Evidence map›Paper›PMID 39614929›Full record

ArticleHistochemistry and cell biology2024

A hypothesis of mesenchymal stem cell osteogenic differentiation mediated by chelidonic acid through the calcium import: original research and computer simulation.

Temur Nasibov, Anna Gorokhova, Ekaterina Porokhova, Valeria Shupletsova, Kristina Yurova, Elena Avdeeva, Usman Bariev, Larisa Litvinova, Mikhail Belousov, Igor Khlusov

Abstract read
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In one paragraph

Article in Histochemistry and cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Chelidonic acid amelioratesFrontiers in immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Temur NasibovLaboratory of Cellular and Microfluidic Technologies, Siberian State Medical University, 634050, Tomsk, Russian Federation.ORCID http://orcid.org/0000-0002-8056-3967
Anna GorokhovaLaboratory of Cellular and Microfluidic Technologies, Siberian State Medical University, 634050, Tomsk, Russian Federation.ORCID http://orcid.org/0000-0001-8401-7181
Ekaterina PorokhovaLaboratory of Cellular and Microfluidic Technologies, Siberian State Medical University, 634050, Tomsk, Russian Federation.ORCID http://orcid.org/0000-0002-7317-2036
Valeria ShupletsovaCenter for Immunology and Cellular Biotechnologies, Immanuel Kant Baltic Federal University, 236041, Kaliningrad, Russian Federation.ORCID http://orcid.org/0000-0001-7243-9731
Kristina YurovaCenter for Immunology and Cellular Biotechnologies, Immanuel Kant Baltic Federal University, 236041, Kaliningrad, Russian Federation.ORCID http://orcid.org/0000-0001-6146-3330
Elena AvdeevaLaboratory of Cellular and Microfluidic Technologies, Siberian State Medical University, 634050, Tomsk, Russian Federation.ORCID http://orcid.org/0000-0001-7061-9843
Usman BarievLaboratory of Cellular and Microfluidic Technologies, Siberian State Medical University, 634050, Tomsk, Russian Federation.ORCID http://orcid.org/0009-0002-7547-2558
Larisa LitvinovaCenter for Immunology and Cellular Biotechnologies, Immanuel Kant Baltic Federal University, 236041, Kaliningrad, Russian Federation.ORCID http://orcid.org/0000-0001-5231-6910
Mikhail BelousovLaboratory of Cellular and Microfluidic Technologies, Siberian State Medical University, 634050, Tomsk, Russian Federation.ORCID http://orcid.org/0000-0002-2153-7945
Igor KhlusovLaboratory of Cellular and Microfluidic Technologies, Siberian State Medical University, 634050, Tomsk, Russian Federation. khlusov.ia@ssmu.ru.ORCID http://orcid.org/0000-0003-3465-8452

Funding

Kant Baltic Federal University, state assignment FZWM-2024-0012
6 · The paper itself

Abstract

Chelidonic acid (ChA) is small molecule capable of inducing the differentiation of mesenchymal stem cells (MSCs) into osteoblasts and the formation of mineralized bone matrix (MBM) both in vitro and in vivo. However, the molecular mechanisms underlying these effects are unknown. Therefore, in silico modelling of potential molecular targets of ChA was performed. ChA was isolated from Saussurea controversa. The ability of ChA to induce in vitro differentiation MSCs into osteoblasts synthesizing MBM was detected using alizarin red staining. ChA osteogenic activity was studied in mice by in situ test of ectopic osteogenesis, using the subcutaneous implantation of syngeneic bone marrow on the calcium phosphate coated titanium plates. DIGEP-Pred web service was used to simulate in silico the effect of ChA on gene expression, and overrepresentation analysis to search for common ontologies and pathways. ChA linearly increased the number of single (R

Indexed as

CalciumCell DifferentiationComputer SimulationMesenchymal Stem CellsOsteogenesisAnimalsCells, CulturedMiceCalciumChelidonic acidIn silico analysisMesenchymal stromal/stem cellsOsteogenesisSignalling pathwaysTarget genes

Identifiers

PMID39614929

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.