Evidence map›Paper›PMID 39614920›Full record

ArticleBiochemical genetics2025

Altered Mitochondrial DNA Copy Number and Telomere Length in Patients with Substance Use Disorder: Correlation with Age, Sex, and Chronic Diseases.

Teodora Taseva, Yana Koycheva, Rositsa Racheva, Tsveta Raycheva, Yordan Hodzhev, Emilia Nikolova, Mila Ilieva, Maria Krasteva

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Article in Biochemical genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Teodora TasevaInstitute of Plant Physiology and Genetics, Laboratory of Genome Dynamics and Stability, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Street, Bldg. 21, 1113, Sofia, Bulgaria.
Yana KoychevaInstitute of Plant Physiology and Genetics, Laboratory of Genome Dynamics and Stability, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Street, Bldg. 21, 1113, Sofia, Bulgaria.
Rositsa RachevaInstitute for Population and Human Studies, Department of Psychology, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Street, Bldg. 6, 1113, Sofia, Bulgaria.
Tsveta RaychevaDepartment of Addictions, National Center for Public Health and Analyses, Acad. Ivan Ev. Geshov Street 15, 1431, Sofia, Bulgaria.
Yordan HodzhevNational Centre of Infectious and Parasitic Diseases, 1504, Sofia, Bulgaria.
Emilia NikolovaDepartment of Medical Chemistry and Biochemistry, Medical University of Sofia, 1431, Sofia, Bulgaria.
Mila IlievaFaculty of Biology, Sofia University 'St. Kliment Ohridski', 1164, Sofia, Bulgaria.
Maria KrastevaInstitute of Plant Physiology and Genetics, Laboratory of Genome Dynamics and Stability, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Street, Bldg. 21, 1113, Sofia, Bulgaria. maria_krasteva@abv.bg.

Funding

Bulgarian National Science Fund (BNSF), Ministry of Education and Science, Bulgaria Grant number KP-06-H25/5
6 · The paper itself

Abstract

Substance use disorder (SUD) is a complex condition involving psychological, sociocultural, and genetic factors. In this study, we examined the alternations in mitochondrial DNA copy number (mtDNAcn) and telomere length (TL) and their relationship to demographic, medical, heredity, and substance use characteristics in patients with SUD and healthy controls. We investigated a total cohort of 54 participants: 21 healthy individuals, 17 patients with alcohol dependence (AD), and 16 patients with drug dependence (DD). TL and mtDNAcn were measured using quantitative real-time PCR, with statistical methods used to assess the association between variables. We observed a significant decrease in mtDNAcn in both SUD groups, particularly associated with chronic diseases in the AD group. No significant differences in TL were found among the three groups. Sex-associated analysis revealed a significant mtDNAcn reduction in the DD males and elevated TL in AD males compared to control males. Correlation analyses showed associations between the two biomarkers and age, sex, and chronic diseases. Our findings suggest that leukocyte mtDNAcn is a more sensitive marker than TL in patients with SUD, indicating sex-specific patterns of alterations. These findings require confirmation through larger cohort recruitment.

Indexed as

DNA, MitochondrialSubstance-Related DisordersTelomereTelomere HomeostasisAdultAgedChronic DiseaseDNA Copy Number VariationsFemaleHumansMaleMiddle AgedPrincipal Component AnalysisReal-Time Polymerase Chain ReactionDNA, MitochondrialAlcohol addictionDrug addictionLeukocytesmtDNAcnTL

Identifiers

PMID39614920

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.