Evidence map›Paper›PMID 39614905›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2025

Age-related variations in heart rate variability profiles among patients with schizophrenia and major depressive disorder.

YuQing Gao, LinLin Zhou, HaiSu Wu, YanYan Wei, XiaoChen Tang, LiHua Xu, YeGang Hu, Qiang Hu, HaiChun Liu, ZiXuan Wang and 5 more

Abstract read
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In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

YuQing Gao *Shanghai Mental Health Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, China.
LinLin Zhou *Shanghai Mental Health Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, China.
HaiSu Wu *Shanghai Mental Health Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, China.
YanYan WeiShanghai Mental Health Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, China.
XiaoChen TangShanghai Mental Health Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, China.
LiHua XuShanghai Mental Health Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, China.
YeGang HuShanghai Mental Health Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, China.
Qiang HuDepartment of Psychiatry, ZhenJiang Mental Health Center, Zhenjiang, PR China.
HaiChun LiuDepartment of Automation, Shanghai Jiao Tong University, Shanghai, 200240, China.
ZiXuan WangShanghai Xinlianxin Psychological Counseling Center, Shanghai, China.
Tao ChenBig Data Research Lab, University of Waterloo, Waterloo, ON, Canada.
ChunBo LiShanghai Mental Health Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, China.
YanLi LuoDepartment of Psychological Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. luoluoyanli@163.com.
JiJun WangShanghai Mental Health Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, China. jijunwang27@163.com.
TianHong ZhangShanghai Mental Health Center, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of Medicine, 600 Wanping Nan Road, Shanghai, 200030, China. zhang_tianhong@126.com.ORCID http://orcid.org/0000-0002-5379-7119

Funding

Ministry of Science and Technology of the People's Republic of China 2023YFC2506800National Natural Science Foundation of China 82171544, 82371505, 82151314, 82101623, 82271548, U22A20305
6 · The paper itself

Abstract

Patients with psychiatric disorders exhibit general autonomic dysregulation and elevated cardiovascular risks, which could be indexed by heart rate variability (HRV). However, HRV is susceptible to age and other patient-specific factors. This study aimed to investigate the HRV profile and age-related variations, as well as the potential influence of sex, BMI, and HR on HRV in psychiatric populations. There were 571 consecutive patients diagnosed with schizophrenia (SZ) (N = 282) or major depressive disorder (MDD) (N = 289) recruited and classified as adolescent (11-21 years) and adult (> 21 years) groups. HRV indices were measured with 3-minute resting ECG recordings. Compared to adolescent subjects, all time-domain and nonlinear HRV indices were notably reduced in adults, while frequency-domain HRV was comparable. Between SZ and MDD groups, only HTI differed significantly. Age and psychiatric disorders exhibited complex interaction effects on HRV. Stratified by age stage, MDD patients exhibited slightly higher HRV in adolescence but slightly lower HRV in adulthood. In logistic regression analysis, HTI and SD2 were significantly distinctive between adolescents and adults in MDD group, while pNN50 was distinctive in SZ group. Moreover, female subjects demonstrated lower time-domain HRV, LF/HF and SD2 than males. HR exhibited inverse relationship with three domain HRV. No significant effect of BMI was observed. In psychiatric populations, compared to adolescents, adults decreased in time-domain and nonlinear HRV, but not in frequency-domain HRV. Age and psychotic disorders exhibited complex interaction effects on HRV. Sex and HR also emerged as important influencing factors of HRV.

Indexed as

AgingHeart RateMajor Depressive DisorderSchizophreniaAdolescentAdultAge FactorsChildElectrocardiographyFemaleHumansMaleMiddle AgedSex FactorsYoung AdultAge effectGenderHeart rate variabilityMood disorderPsychosis

Identifiers

PMID39614905

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.