Evidence map›Paper›PMID 39614888›Full record

ArticleEuropean journal of nutrition2024

Frequent intake of high fiber and probiotic diets lowers risks associated with atopic dermatitis and house dust mite allergy: a cross-sequential study of young Chinese adults from Singapore and Malaysia.

Jun Jie Lim, Kavita Reginald, Yee-How Say, Mei Hui Liu, Fook Tim Chew

Abstract read
In one paragraph

Article in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Healthy Diet Intervention for Treating Atopic Dermatitis: A Pilot Randomised Controlled Trial.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jun Jie LimDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Allergy and Molecular Immunology Laboratory, Lee Hiok Kwee Functional Genomics Laboratories, Block S2, Level 5, 14 Science Drive 4, off Lower Kent Ridge Road, Singapore, 117543, Singapore.
Kavita ReginaldDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Allergy and Molecular Immunology Laboratory, Lee Hiok Kwee Functional Genomics Laboratories, Block S2, Level 5, 14 Science Drive 4, off Lower Kent Ridge Road, Singapore, 117543, Singapore.
Yee-How SayDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Allergy and Molecular Immunology Laboratory, Lee Hiok Kwee Functional Genomics Laboratories, Block S2, Level 5, 14 Science Drive 4, off Lower Kent Ridge Road, Singapore, 117543, Singapore.
Mei Hui LiuDepartment of Food Science & Technology, Faculty of Science, National University of Singapore, Singapore, 117543, Singapore.
Fook Tim ChewDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Allergy and Molecular Immunology Laboratory, Lee Hiok Kwee Functional Genomics Laboratories, Block S2, Level 5, 14 Science Drive 4, off Lower Kent Ridge Road, Singapore, 117543, Singapore. dbscft@nus.edu.sg.ORCID http://orcid.org/0000-0003-1337-5146

Funding

Agency for Science Technology and Research (A*STAR) (Singapore) APG2013/108Agency for Science Technology and Research (A*STAR) (Singapore) H17/01/a0/008Biomedical Research Council BMRC/01/1/21/18/077Biomedical Research Council BMRC/04/1/21/19/315Biomedical Research Council BMRC/APG2013/108National Medical Research Council NMRC/1150/2008National Medical Research Council OFIRG20nov-0033National Research Foundation Singapore NRF-MP-2020-0004National University of Singapore N-154-000-038-001Singapore Food Agency SFS_RND_SUFP_001_04Singapore Food Agency W22W3D0006Singapore Immunology Network SIgN-06-006Singapore Immunology Network SIgN-08-020Singapore Ministry of Education Academic Research Fund R-154-000-191-112Singapore Ministry of Education Academic Research Fund R-154-000-404-112Singapore Ministry of Education Academic Research Fund R-154-000-553-112Singapore Ministry of Education Academic Research Fund R-154-000-565-112Singapore Ministry of Education Academic Research Fund R-154-000-630-112Singapore Ministry of Education Academic Research Fund R-154-000-A08-592Singapore Ministry of Education Academic Research Fund R-154-000-A27-597Singapore Ministry of Education Academic Research Fund R-154-000-A91-592Singapore Ministry of Education Academic Research Fund R-154-000-A95-592Singapore Ministry of Education Academic Research Fund R-154-000-B99-114
6 · The paper itself

Abstract

purposeDietary fiber intake may influence the risk and severity of atopic dermatitis (AD), a common chronic allergic skin condition. This cross-sequential study investigated the association between dietary fiber intake and various characteristics of AD, including house dust mites (HDM) allergy and dry skin, in 13,561 young Chinese adults (mean years = 22.51, SD ± 5.90) from Singapore and Malaysia.

methodsDietary habits were assessed using a validated semi-quantitative, investigator-administered food frequency questionnaire from the International Study of Asthma and Allergies in Childhood. We derived an amount-based dietary index to estimate fiber intake while studying its correlation with probiotic drinks intake. AD status was determined by skin prick tests for HDM and symptomatic histories of eczema. Multivariable logistic regression analysis, adjusting for demographic, genetic predisposition, body mass index and lifestyle factors, and synergy factor analysis were used to explore the association and interaction of dietary factors on disease outcomes.

resultsHigh fiber intake (approximately 98.25 g/serving/week) significantly lowered the associated risks for HDM allergy (Adjusted Odds Ratio [AOR]: 0.895; 95% Confidence Intervals [CI]: 0.810-0.989; adjusted p-value < 0.05) and AD (AOR: 0.831; 95% CI: 0.717-0.963; adjusted p-value < 0.05), but not dry skin. While probiotic intake was not associated with AD, it was significantly correlated with fiber intake (R

conclusionA high-fiber diet is associated with AD and HDM allergy. Moderate-to-high fiber intake, particularly in conjunction with probiotics, may further mitigate AD risks.

Indexed as

Dermatitis, AtopicDietary FiberProbioticsPyroglyphidaeAdolescentAdultAnimalsChinaCross-Sectional StudiesDietDust Mite AllergyEast Asian PeopleFemaleHumansHypersensitivityMalaysiaDietary FiberAllergy sensitizationAtopic dermatitisDietary fibersEpidemiologyEthnic Chinese

Identifiers

PMID39614888
PMCPMC11608386

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.