Evidence map›Paper›PMID 39614812›Full record

ArticleJournal of the American Chemical Society2025

Bioorthogonal Activation of Deep Red Photoredox Catalysis Inducing Pyroptosis.

Jungryun Kim, Yunjie Xu, Jong Hyeon Lim, Jin Yong Lee, Mingle Li, Joseph M Fox, Marc Vendrell, Jong Seung Kim

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  19. Photocatalyzed elaboration of antibody-based bioconjugates.Beilstein journal of organic chemistry · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jungryun KimDepartment of Chemistry, Korea University, Seoul 02841, Korea.
Yunjie XuDepartment of Chemistry, Korea University, Seoul 02841, Korea.
Jong Hyeon LimDepartment of Chemistry, Sungkyunkwan University, Suwon 16419, Korea.
Jin Yong LeeDepartment of Chemistry, Sungkyunkwan University, Suwon 16419, Korea.ORCID 0000-0003-0360-5059
Mingle LiCollege of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0002-0384-9128
Joseph M FoxDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.ORCID 0000-0002-8258-1640
Marc VendrellCentre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh EH16 4UU, United Kingdom.
Jong Seung KimDepartment of Chemistry, Korea University, Seoul 02841, Korea.ORCID 0000-0003-3477-1172

Funding

Toolkit for Fast, Multipurpose and Inducible Bioorthogonal ChemistryR01GM132460 · NIGMS · UNIVERSITY OF DELAWARE · PI JOSEPH M FOX · 2019 to 2026
$4.2M
Development of an Efficient 18F labeling technology based on tetrazine trans-cyclooctene ligationR01CA287184 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JOSEPH M FOX, Zibo Li · 2024 to 2026
$1.9M
NCI NIH HHS R01 CA287184NIGMS NIH HHS R01 GM132460
6 · The paper itself

Abstract

The revolutionary impact of photoredox catalytic processes has ignited novel avenues for exploration, empowering us to delve into nature in unprecedented ways and to pioneer innovative biotechnologies for therapy and diagnosis. However, integrating artificial photoredox catalysis into living systems presents significant challenges, primarily due to concerns over low targetability, low compatibility with complex biological environments, and the safety risks associated with photocatalyst toxicity. To address these challenges, herein, we present a novel bioorthogonally activatable photoredox catalysis approach. In this approach, potent photocatalyst selection via atom replacement of the rhodamine core yielded the bioorthogonally activatable photocatalyst (

Indexed as

Oxidation-ReductionPhotochemical ProcessesPyroptosisCatalysisCell Line, TumorCycloaddition ReactionCyclooctanesHumansLightMitochondriaMolecular StructureNADRhodaminesCyclooctanesNADRhodamines

Identifiers

PMID39614812
PMCPMC12832188

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.