Evidence map›Paper›PMID 39614766›Full record

ArticleTransfusion2025

Impact of iron supplementation among anemic voluntary first-time blood donors: Results from the BLOODSAFE pilot trial in Ghana.

Yvonne Dei-Adomakoh, Edeghonghon Olayemi, Susan Telke, Lucy Asamoah-Akuoko, Bernard Appiah, Catherine Segbefia, Caitlin Ward, Tara Tancred, Alfred Edwin Yawson, Seth Adu-Afarwuah and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transfusion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yvonne Dei-AdomakohDepartment of Haematology, University of Ghana Medical School, Accra, Ghana.
Edeghonghon OlayemiDepartment of Haematology, University of Ghana Medical School, Accra, Ghana.
Susan TelkeCoordinating Centers for Biometric Research, Division of Biostatistics, University of Minnesota Research, City-Twin cities, minnesota, USA.
Lucy Asamoah-AkuokoPlanning Monitoring & Evaluation Department, National Blood Service, Accra, Ghana.
Bernard AppiahDepartment of Public Health, Syracuse University, Syracuse, New York, USA.
Catherine SegbefiaDepartment of Child Health, University of Ghana Medical School, Accra, Ghana.
Caitlin WardCoordinating Centers for Biometric Research, Division of Biostatistics, University of Minnesota Research, City-Twin cities, minnesota, USA.
Tara TancredDepartment of International Public Health, Liverpool School of Tropical Medicine, Liverpool, UK.
Alfred Edwin YawsonDepartment of Community Health, University of Ghana Medical School, Accra, Ghana.
Seth Adu-AfarwuahDepartment of Nutrition and Food Science, University of Ghana, Accra, Ghana.
Amma Benneh Akwasi-KumaDepartment of Haematology, University of Ghana Medical School, Accra, Ghana.
Solomon Fiifi Ofori-AcquahSchool of Biomedical & Allied Health Sciences, College of Health Sciences, University of Ghana, Accra, Ghana.
Philip Baba AdongoDepartment of Social & Behavioural Sciences, School of Public Health, University of Ghana, Accra, Ghana.
Michael Ebo AcquahDepartment of Haematology, University of Ghana Medical School, Accra, Ghana.
Reena AmetorwoDepartment of Haematology, University of Ghana Medical School, Accra, Ghana.
Imelda BatesThe Centre for Capacity Research, Liverpool School of Tropical Medicine, Liverpool, UK.ORCID https://orcid.org/0000-0002-0862-8199
Francis AgyeiDepartment of Family and Community Health, University of Health and Allied Sciences, Hohoe, Ghana.
Meghan DelaneyDivision of Pathology & Laboratory Medicine, Children's National Hospital, Washington, DC, USA.ORCID https://orcid.org/0000-0003-1089-5787
Cavan ReillyCoordinating Centers for Biometric Research, Division of Biostatistics, University of Minnesota Research, City-Twin cities, minnesota, USA.
BLOODSAFE investigators

Funding

The BLOODSAFE Data Coordinating Center: A Data Center for More SafeTransfusions in Sub-Saharan AfricaU24HL151541 · NHLBI · UNIVERSITY OF MINNESOTA · PI REILLY, CAVAN S. · 2020 to 2025
$5.5M
Development and evaluation of community-based approaches and donor care intervention models for improving availability and safety of blood for the management of severe anemia in GhanaUH3HL151599 · NHLBI · UNIVERSITY OF GHANA · PI ASAMOAH-AKUOKO, LUCY, DEI-ADOMAKOH, YVONNE · 2022 to 2025
$2.3M
Development and evaluation of community-based approaches and donor care intervention models for improving availability and safety of blood for the management of severe anemia in GhanaUG3HL151599 · NHLBI · UNIVERSITY OF GHANA · PI ASAMOAH-AKUOKO, LUCY, DEI-ADOMAKOH, YVONNE · 2020 to 2021
$470k
NHLBI NIH HHS 1UG3HL151599-01NHLBI NIH HHS U24 HL151541NHLBI NIH HHS UG3 HL151599NHLBI NIH HHS UH3 HL151599
6 · The paper itself

Abstract

introductionIn sub-Saharan Africa (SSA), an adequate supply of safe blood for transfusion is a major developmental challenge. In Ghana, deferral from blood donation for anemia accounts for nearly half of the ineligible blood donors. We conducted a longitudinal two-arm parallel-group non-inferiority trial to test if iron supplementation among blood donors with iron deficiency (ID) or anemia could increase their hemoglobin levels to near those without ID or anemia. MATERIALS AND

methodsA structured questionnaire was used to collect participants' sociodemographic and medical information after written informed consent was obtained. Blood samples were analyzed for full blood count (FBC), serum ferritin, malaria rapid test, and a peripheral blood smear. The primary outcome was hemoglobin level after 4 months comparing anemic donors who received iron supplementation to the standard of care participants, nonanemic donors who did not receive iron supplementation. All donors received nutritional counseling.

resultsAdherence to low-dose iron supplementation three times a week was poor. Hemoglobin levels in the iron supplementation arm were not close enough to those in the control group after 4 months of iron supplementation to declare non-inferiority. However, non-inferiority was met when the 4 month hemoglobin comparison was restricted to female donors.

conclusionAfter 4 months of iron supplementation, hemoglobin levels in the iron supplementation group did not sufficiently match those in the control group to declare non-inferiority. Data from this pilot trial informed and shaped the design of a larger randomized control type 1 pragmatic effectiveness implementation hybrid trial which is currently ongoing.

Indexed as

AnemiaAnemia, Iron-DeficiencyBlood DonorsDietary SupplementsIronAdultFemaleGhanaHemoglobinsHumansMaleMiddle AgedPilot ProjectsHemoglobinsIronfirst‐time blood donorsGhanairon supplementationnutritional counselingvoluntary

Identifiers

PMID39614766
PMCPMC11750598

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.