Evidence map›Paper›PMID 39614598›Full record

ArticleJournal of feline medicine and surgery2024

Transmucosal glucagon rapidly increases blood glucose concentration in healthy cats.

Emily A Cohen, Lauren Porter, Chiquitha D Crews, Jocelyn Mott, Antonio M Tardo, Chen Gilor

Abstract readRandomized Controlled Trial, VeterinaryClinical Trial, Veterinary
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of feline medicine and surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emily A CohenDepartment of Small Animal Clinical Sciences, University of Florida, College of Veterinary Medicine, Gainesville, FL, USA.ORCID 0009-0000-5183-2462
Lauren PorterDepartment of Small Animal Clinical Sciences, University of Florida, College of Veterinary Medicine, Gainesville, FL, USA.ORCID 0009-0002-0015-3237
Chiquitha D CrewsDepartment of Small Animal Clinical Sciences, University of Florida, College of Veterinary Medicine, Gainesville, FL, USA.ORCID 0000-0002-9034-4143
Jocelyn MottDepartment of Small Animal Clinical Sciences, University of Florida, College of Veterinary Medicine, Gainesville, FL, USA.
Antonio M TardoDepartment of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, Italy.ORCID 0009-0009-3636-0415
Chen GilorDepartment of Small Animal Clinical Sciences, University of Florida, College of Veterinary Medicine, Gainesville, FL, USA.ORCID 0000-0003-0393-4135

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the effect of transmucosal glucagon powder (Baqsimi; Amphastar Pharmaceuticals) on blood glucose (BG) concentrations in healthy cats and describe adverse reactions to its administration.

methodsA randomized, controlled, crossover study was conducted on six healthy cats with a 7-day washout period between treatments. Transmucosal glucagon powder was administered intranasally and rectally and compared with intranasal placebo. Blood was collected at -15 and -1 mins before glucagon administration and 5, 15, 25, 35, 45 and 60 mins after to evaluate BG, plasma glucagon concentrations (pGlucagon) and plasma potassium concentrations (K

resultsMedian pGlucagon in the nasal and rectal groups increased from baseline (nasal: 12.2 pmol/l, range 3.5-44.1; rectal: 6.9 pmol/l, range 2.9-21.1) to 218.5 pmol/l (range 7.9-349.8; CONCLUSIONS AND RELEVANCE: Transmucosal glucagon administration is effective in raising BG with minimal side effects in healthy cats. Future studies are needed to quantify the efficacy and safety of transmucosal glucagon in diabetic cats, especially during hypoglycemic crises.

Indexed as

Blood GlucoseGlucagonAdministration, IntranasalAdministration, RectalAnimalsCatsCross-Over StudiesFemaleMalePotassiumBlood GlucoseGlucagonPotassiumdiabetes mellitusHypoglycemiainsulinintranasalrectal

Identifiers

PMID39614598
PMCPMC11607742

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.