Evidence map›Paper›PMID 39614424›Full record

ArticleJournal of cellular and molecular medicine2024

Hepatocyte-Specific HuR Protects Against Acetaminophen-Induced Liver Injury in Mice.

Linlin Lu, Jicui Chen, Hui Jiang, Ni Li, Xiaojie Li, Yinghao Liu, Chen Zong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Linlin LuInstitute of Medical Sciences, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Jicui ChenDepartment of Blood Transfusion, Qilu Hospital of Shandong University, Jinan, China.
Hui JiangInstitute of Medical Sciences, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Ni LiDepartment of Cell Biology, Shandong University School of Medicine, Jinan, China.
Xiaojie LiDepartment of Cell Biology, Shandong University School of Medicine, Jinan, China.
Yinghao LiuDepartment of Cell Biology, Shandong University School of Medicine, Jinan, China.
Chen ZongInstitute of Medical Sciences, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.ORCID 0000-0003-3123-1787

Funding

Provincial Natural Science Foundation of Shandong ZR2020QH087Provincial Natural Science Foundation of Shandong ZR2021QH118
6 · The paper itself

Abstract

Acetaminophen (APAP) overdose is a major cause of drug-induced liver injury (DILI) in many countries. Hepatocyte proliferation, autophagy and antioxidant capacity are crucial to the prognosis of APAP-induced liver injury, but the underlying mechanisms are not fully understood. Here, we found that human antigen R (HuR) protein expression was markedly increased in the model of APAP-induced liver injury, and conditional hepatocyte-specific HuR knockout aggravated APAP-induced liver injury in mice. Further investigation of the underlying mechanisms of HuR's protective effects showed that conditional hepatocyte-specific HuR knockout reduced the protein expression of cyclin A1, cyclin B1, cyclin D1, CDK2, ATG3, ATG5, ATG7 and NRF2 in mice, reducing hepatocyte proliferation, autophagy and antioxidant capacity. Mechanistically, HuR could physically associate with the 3'-untranslated regions (UTRs) of cyclin A1, cyclin B1, cyclin D1, Cdk2, Atg3, Atg5, Atg7 and Nrf2 mRNAs, thereby regulating their translation. These findings suggest that HuR attenuates APAP-induced liver injury by regulating hepatocyte proliferation, autophagy and antioxidant capacity.

Indexed as

AcetaminophenAutophagyCell ProliferationChemical and Drug Induced Liver InjuryELAV-Like Protein 1HepatocytesMice, Knockout3' Untranslated RegionsAnimalsAntioxidantsDisease Models, AnimalMaleMiceMice, Inbred C57BLNF-E2-Related Factor 23' Untranslated RegionsAcetaminophenAntioxidantsElavl1 protein, mouseELAV-Like Protein 1NF-E2-Related Factor 2APAP‐induced liver injuryautophagyhepatocyte proliferationHuRoxidative stress

Identifiers

PMID39614424
PMCPMC11606931

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.