Evidence map›Paper›PMID 39614240›Full record

ReviewMicrobial cell factories2024

Regulatory mechanisms of acetic acid, ethanol and high temperature tolerances of acetic acid bacteria during vinegar production.

Shengkai Hua, Yuqin Wang, Leyi Wang, Qinxuan Zhou, Zhitao Li, Peng Liu, Ke Wang, Yuanyuan Zhu, Dong Han, Yongjian Yu

Abstract readReview
In one paragraph

Review in Microbial cell factories, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Pulsed Electric Field Inactivation ofFoods (Basel, Switzerland) · 2025
    Article
  11. Peptidoglycan LD-Transpeptidases.Antibiotics (Basel, Switzerland) · 2025
    Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shengkai HuaSchool of Grain Science and Technology, Jiangsu University of Science and Technology, Zhenjiang, 212100, China.
Yuqin WangSchool of Grain Science and Technology, Jiangsu University of Science and Technology, Zhenjiang, 212100, China. yqwang@just.edu.cn.
Leyi WangSchool of Grain Science and Technology, Jiangsu University of Science and Technology, Zhenjiang, 212100, China.
Qinxuan ZhouSchool of Grain Science and Technology, Jiangsu University of Science and Technology, Zhenjiang, 212100, China.
Zhitao LiSchool of Grain Science and Technology, Jiangsu University of Science and Technology, Zhenjiang, 212100, China.
Peng LiuSchool of Grain Science and Technology, Jiangsu University of Science and Technology, Zhenjiang, 212100, China.
Ke WangSchool of Grain Science and Technology, Jiangsu University of Science and Technology, Zhenjiang, 212100, China.
Yuanyuan ZhuSchool of Grain Science and Technology, Jiangsu University of Science and Technology, Zhenjiang, 212100, China.
Dong HanSchool of Grain Science and Technology, Jiangsu University of Science and Technology, Zhenjiang, 212100, China.
Yongjian YuSchool of Grain Science and Technology, Jiangsu University of Science and Technology, Zhenjiang, 212100, China. yuyj@just.edu.cn.

Funding

National Natural Science Foundation of China 32072202National Natural Science Foundation of China 32202002
6 · The paper itself

Abstract

Acetic acid bacteria (AAB) play a pivotal role in the food fermentation industry, especially in vinegar production, due to their ability to partially oxidize alcohols to acetic acid. However, economic bioproduction using AAB is challenged by harsh environments during acetic acid fermentation, among which initial ethanol pressure, subsequent acetic acid pressure, and consistently high temperatures are common experiences. Understanding the stress-responsive mechanisms is essential to developing robust AAB strains. Here, we review recent progress in mechanisms underlying AAB stress response, including changes in cell membrane composition, increased activity of membrane-bound enzymes, activation of efflux systems, and the upregulation of stress response molecular chaperones. We also discuss the potential of advanced technologies, such as global transcription machinery engineering (gTME) and Design-Build-Test-Learn (DBTL) approach, to enhance the stress tolerance of AAB, aiming to improve vinegar production.

Indexed as

Acetic AcidEthanolFermentationHot TemperatureAcetic AcidEthanolAcetic acidAcetic acid bacteriaEthanolStress-responsive mechanismsThermotolerantVinegar

Identifiers

PMID39614240
PMCPMC11607832

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.