ArticleBMC nephrology2024
Association of insulin resistance with chronic kidney disease in individuals without diabetes in a community population in South China.
Article in BMC nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Review
- Association Between Estimated Glucose Disposal Rate and Biological Aging Among U.S. Adults: A Cross-Sectional Study.Health science reports · 2026Article
- The Neuro-Cardio-Renal Stress Index (NCR-SI): A Pragmatic Composite Framework for Characterizing Multisystem Burden in Multimorbid Patients.Diagnostics (Basel, Switzerland) · 2026Article
- Machine learning model based on routine blood and biochemical parameters for early diagnosis of diabetic kidney disease.Frontiers in endocrinology · 2026Article
- Correspondence: insulin resistance and chronic kidney disease in patients without diabetes.BMC nephrology · 2025Article
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4 authors.
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Abstract
backgroundTo explore the relationship of insulin resistance (IR) with chronic kidney disease (CKD) in individuals without diabetes.
methodsWe performed a cross-sectional survey among 2142 community-based participants without diabetes from southern China from June to October 2012 and excluded the incomplete data. We divided all the participants into four groups according to the quartiles of homeostasis model assessment of IR (HOMA-IR). Logistic regression models were used to explore the associations of IR with CKD in these subjects.
resultsIn the unadjusted model, compared with the quartile one group, IR was significantly associated with CKD (odds ratio [OR] = 2.24, P < 0.001; OR = 4.46, P < 0.001) in the quartile three and four groups, and the association was still significant (OR = 2.08, P = 0.005; OR = 3.89, P < 0.001 ) after adjusting for potential confounders (including age, current smoker, current alcohol use, physical inactivity, education level, systolic blood pressure, diastolic blood pressure, serum triglyceride, and body mass index). The area under the receiver operating characteristic curve (95% confidence interval) of HOMA-IR for diagnosing CKD was 0.67 (0.64, 0.71). The cut-off value was 2.5, the sensitivity was 75.2%, and the specificity was 56.4%.
conclusionsIR is associated with Chronic Kidney Disease (CKD) in participants without diabetes. It has been proposed that CKD patients may benefit from reducing their insulin resistance.
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