ArticleBMC microbiology2024
Unique genital microbiota in male lichen sclerosus urethral stricture associated with urine exposure.
Article in BMC microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Pathological phimosis is associated with foreskin immune cell infiltration but not microbiota composition.mSphere · 2026Article
- Penile microbiome in histopathologically confirmed lichen sclerosus: a comparative study of urethral and preputial swabs.World journal of urology · 2025Article
- Multi-omics analysis reveals the host-microbe interactions on the dysbiosis of tissue microbiota in male genital lichen sclerosus-induced urethral strictures.Microbiology spectrum · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLichen sclerosus (LS) is a chronic inflammatory cicatricial skin disease that can lead to urethral stricture or even malignant transformation and the etiology is still unknown. This study comparatively analyzed the balanopreputial swab and urine microbiota simultaneously between male patients with LS urethral stricture (LSUS) and non-LS urethral stricture (non-LSUS).
methodsWe prospectively included 31 male patients with LSUS and 30 with non-LSUS in this case-control study. Midstream urine samples and balanopreputial swabs were collected from each patient for the 16S V3-V4 hypervariable region sequencing. Operational taxonomic units were defined using a > 97% sequence similarity threshold. We compared the differences in alpha diversity, beta diversity, and microbial structure between the two groups.
resultsWhether in swab or urine samples, there was no significant difference in alpha diversity between the two groups. Swab samples showed a significant difference in beta diversity (p = 0.001). For all individuals, composition analyses showed that the most abundant phyla were Actinobacteria, Firmicutes, Proteobacteria, and Bacteroidetes in both samples. Additionally, the microbial communities of swab samples were significantly more similar to the communities of urine samples in the LSUS group (p = 0.047).
conclusionsMicrobiota showed significant variation between LSUS and non-LSUS groups, suggesting that microecological imbalance may be closely related to the occurrence of LS. Urinary irritation may be related to the unique microbiota on the genital skin of patients with LSUS.
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