ArticleScientific reports2024
Investigation of the impact of exposure to trace elements on health and disease from the ToxiLaus study.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic determinants of zinc homeostasis and its role in cardiometabolic diseases.PLoS genetics · 2025Pooled it
- Association between urinary heavy metal/trace element concentrations and kidney function: a prospective study.Clinical kidney journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The ToxiLaus study aims at evaluating the impact of environmental toxic species on health and diseases' onset and development. Specifically, the ubiquitous presence of trace elements (TEs) in the environment urges for a better characterization of their influence on human organism. In its primary phase, the ToxiLaus study focused on measuring the urinary concentrations of 23 TEs in the baseline samples from the CoLaus|PsyCoLaus population-based cohort, using inductively coupled plasma mass spectrometry (ICP-MS). Statistical analyses were carried out on 5866 participants, investigating links between TEs concentrations and smoking status, metabolic syndrome and body mass index (BMI). Smoking status was associated with Cd, Zn, Pb, Mo and Hg (respectively OR = 3.64, 1.42, 1.20, 0.69 and 0.58) while metabolic syndrome was associated with Zn and Cd (OR = 1.81 and 1.24 respectively). Concentrations of Zn, Hg, Co, Ni, Cu, Mo, As, Sn, Tl, Fe where significantly different (p < 0.0001) between BMI groups (Normal, Overweight, Obese). Finally, this study provides an overview of the distribution of trace elements in a cohort large sample of the general population, as well as their main associations with cardiovascular risk factors. Theses relations will be further analysed in subsequent phases of the study.
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Registered trials
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