Evidence map›Paper›PMID 39614031›Full record

ArticleNeurochemical research2024

Neuroprotective Effects of Chaperonin Containing TCP1 Subunit 2 (CCT2) on Motor Neurons Following Oxidative or Ischemic Stress.

Hyun Jung Kwon, Hyunwoong Mun, Jae Keun Oh, Goang-Min Choi, Dae Young Yoo, In Koo Hwang, Dae Won Kim, Seung Myung Moon

Abstract read
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Article in Neurochemical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Chaperonin in health and disease.Molecular biomedicine · 2026
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hyun Jung KwonDepartment of Biochemistry and Molecular Biology, Research Institute of Oral Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung, 25457, South Korea.
Hyunwoong MunDepartment of Neurosurgery, College of Medicine, Hallym University Sacred Heart Hospital, Hallym University, Anyang, 14068, South Korea.
Jae Keun OhDepartment of Neurosurgery, College of Medicine, Hallym University Sacred Heart Hospital, Hallym University, Anyang, 14068, South Korea.
Goang-Min ChoiDepartment of Thoracic and Cardiovascular Surgery, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon, 24253, South Korea.
Dae Young YooDepartment of Anatomy and Cell Biology, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, South Korea.
In Koo HwangDepartment of Anatomy and Cell Biology, College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University, Seoul, 08826, South Korea.
Dae Won KimDepartment of Biochemistry and Molecular Biology, Research Institute of Oral Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung, 25457, South Korea. kimdw@gwnu.ac.kr.
Seung Myung MoonDepartment of Neurosurgery, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, 07441, South Korea. nsmsm@hallym.ac.kr.

Funding

Ministry of Science, ICT and Future Planning NRF-2021R1F1A1049744
6 · The paper itself

Abstract

Chaperonin containing TCP1 (CCT) is an essential protein that controls proteostasis following spinal cord damage. In particular, CCT2 plays an important role in neuronal death in various neurological disorders; however, few studies have investigated the effects of CCT2 on ischemic damage in the spinal cord. In the present study, we synthesized a cell-permeable Tat-CCT2 fusion protein and observed its effects on H

Indexed as

Hydrogen PeroxideMotor NeuronsNeuroprotective AgentsOxidative StressAnimalsCell LineChaperonin Containing TCP-1MaleMiceRabbitsReactive Oxygen SpeciesSpinal CordSpinal Cord IschemiaChaperonin Containing TCP-1Hydrogen PeroxideNeuroprotective AgentsReactive Oxygen SpeciesCCT2FerroptosisInflammatory cytokineIschemiaNeuroprotectionOxidative damage

Identifiers

PMID39614031

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.