SynthesisDigestive diseases and sciences2025
12-mm Versus 10-mm Metallic Stents for Malignant Biliary Obstructions: A Systematic Review and Meta-Analysis.
Synthesis in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Comparison of fully covered self-expandable metal stents with and without antimigration fins for the management of distal malignant biliary obstruction.Gastrointestinal endoscopy · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsEndoscopic drainage of malignant biliary obstruction using metal stents is widely used to treat obstructive jaundice. However, the occurrence of stent occlusion or migration raises the hypothesis using stents with larger diameters may be associated with better outcomes.
methodsPubMed, Embase, and Cochrane databases were systematically searched for studies comparing 10-mm vs. 12-mm covered metallic stents for recurrent unresectable biliary obstruction. The primary outcomes were recurrent biliary obstruction (RBO) and time to RBO (TRBO). Statistical analyses were performed using R software version 4.3.1. The risk ratio (RR) was used for binary outcomes, with their respective 95% confidence interval (CI). Heterogeneity was assessed using the Cochran Q test and I2 statistics.
resultsWe included five studies-one randomized clinical trial and four cohort studies-totaling 520 patients. Among these, 280 received 10-mm stents, while 240 were treated with 12-mm stents. The 12-mm stent is associated with a greater TRBO (HR 1.72; 95% CI 1.36 to 2.18), lower incidence of RBO (RR 0.59; 95% CI 0.44 to 0.78; I2=34%), and stent obstruction (RR 0.52; 95% CI 0.34 to 0.81; I2=33%). No significant differences were found for stent migration and adverse events rate between groups.
conclusionThe 12-mm metallic stents significantly increase stent patency and reduce the incidence of RBO and stent obstruction in managing recurrent unresectable biliary obstruction, with no differences regarding stent migration and adverse events compared to 10-mm stents.
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