Evidence map›Paper›PMID 39613961›Full record

ArticleEuropean radiology2025

Predicting post-hepatectomy liver failure with T1 mapping-based whole-liver histogram analysis on gadoxetic acid-enhanced MRI: comparison with the indocyanine green clearance test and albumin-bilirubin scoring system.

Jun Li, Yi Li, Yuan-Yuan Chen, Xiao-Ying Wang, Cai-Xia Fu, Robert Grimm, Ying Ding, Meng-Su Zeng

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jun LiDepartment of Radiology, Zhongshan Hospital of Fudan University, Shanghai, China.
Yi LiDepartment of Radiology, Zhongshan Hospital of Fudan University, Shanghai, China.
Yuan-Yuan ChenDepartment of Radiology, Zhongshan Hospital of Fudan University, Shanghai, China.
Xiao-Ying WangDepartment of Liver Oncology, Zhongshan Hospital of Fudan University, Shanghai, China.
Cai-Xia FuSiemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China.
Robert GrimmMR Applications Predevelopment, Siemens Healthineers AG, Forchheim, Germany.
Ying DingDepartment of Radiology, Zhongshan Hospital of Fudan University, Shanghai, China. ding.ying@zs-hospital.sh.cn.ORCID http://orcid.org/0000-0002-4478-3436
Meng-Su ZengDepartment of Radiology, Zhongshan Hospital of Fudan University, Shanghai, China.

Funding

Natural Science Foundation for Young Scientists of China Grant No. 81701682Shanghai Municipal Key Clinical Specialty shslczdzk03202
6 · The paper itself

Abstract

objectivesTo explore the value of T1 mapping-based whole-liver histogram analysis on gadoxetic acid-enhanced MRI for predicting post-hepatectomy liver failure (PHLF).

methodsConsecutive patients from March 2016 to March 2018 who underwent gadoxetic acid-enhanced MRI in our hospital were retrospectively analyzed, and 37 patients were enrolled. Whole-liver T1 mapping-based histogram analysis was performed. The indocyanine green (ICG) clearance tests were performed, and albumin-bilirubin (ALBI) scores were calculated. Univariate and multivariate binary logistic analyses were performed to identify independent predictors for PHLF. Diagnostic performance was evaluated with ROC analysis. Histogram-extracted parameters were also associated with the ICG test and ALBI scoring system.

resultsIn enrolled 37 patients (age 57.19 ± 12.28 years), 28 were male. 35.1% (13/37) of patients developed PHLF. For univariate analysis, pre-contrast T1 relaxation time (T1pre) mean, T1pre 95th percentile, the standard deviation (SD) of T1 relaxation time in hepatobiliary phase (T1HBP SD), T1HBP 95th percentile, T1HBP kurtosis, and ICG percentage retained at 15 min (ICG-R15) showed significant differences between the PHLF and non-PHLF groups (all p < 0.05), whereas the ALBI scores showed no significant differences between the two groups (p = 0.937). Multivariate analysis showed that a higher T1HBP 95th percentile was the independent predictor for PHLF (p < 0.05; odds ratio (OR) = 1.014). In addition, most of the histogram-extracted parameters showed significant correlations to the ICG test.

conclusionsT1 mapping-based whole-liver histogram analysis on gadoxetic acid-enhanced MRI is valuable for PHLF prediction and risk stratification, which outperformed the ICG clearance test and ALBI scoring system. KEY POINTS: Question What is the value of T1 mapping-based whole-liver histogram analysis on gadoxetic acid-enhanced MRI for PHLF? Findings The histogram parameters extracted from gadoxetic acid-enhanced T1 mapping manifested potential for grading liver function preoperatively. Clinical relevance T1 mapping-based whole-liver histogram analysis on gadoxetic acid-enhanced MRI can serve as a convenient one-station radiological tool to help identify potential PHLF risks within the preoperative clinical decision-making framework.

Indexed as

Gadolinium DTPAHepatectomyIndocyanine GreenLiver FailureMagnetic Resonance ImagingPostoperative ComplicationsAgedBilirubinColoring AgentsContrast MediaFemaleHumansLiverLiver Function TestsMaleMiddle AgedBilirubinColoring AgentsContrast MediaGadolinium DTPAgadolinium ethoxybenzyl DTPAIndocyanine GreenGadolinium ethoxybenzyl DTPAIndocyanine greenLiver failureMagnetic resonance imagingRisk assessment

Identifiers

PMID39613961

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