ArticleEuropean radiology2025
Effect of inspiratory lung volume on bronchial and arterial dimensions and ratios on chest computed tomography in patients with chronic obstructive pulmonary disease.
Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- The impact of dornase alfa on imaging features of bronchiectasis.Research square · 2025Article
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6 authors.
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Abstract
backgroundThe assessment of bronchus-artery (BA) metrics on chest CT is important for detecting airway abnormalities. It is less clear how BA metrics are dependent on lung volume.
methodsCTs were obtained from a COPDGene substudy investigating the impact of radiation dose on lung density. Patients with chronic obstructive pulmonary disease underwent a full-dose and a reduced-dose CT in the same imaging session. CTs were automatically analyzed by measuring diameters of the bronchial outer edge (B
resultsOne thousand three hundred nineteen patients with a mean (SD) age of 64.4 (8.7) years were included. Three hundred twenty-nine (124) BA pairs were analyzed per CT. No significant difference was found for TLC-CT in relation to dose (p = 0.17). A ΔTLC-CT% of >10% (found in 121, 9%) led to 0.03 and 0.05 decreases in B
conclusionsVariations in TLC over 10% between time points significantly influence bronchial dimensions, affecting BA metrics. Standardizing volumes is recommended for sensitive tracking of airway disease changes over time. KEY POINTS: Question Are BA metrics dependent on total lung capacity (TLC), and if so, how? Findings TLC variations over 10% between time points significantly influence bronchial dimensions, affecting BA metrics. Variations below 10% between CT scans have little effect on BA metrics. Clinical relevance Small lung volume differences between chest CTs have little impact on bronchus and artery metrics; it is imperative to standardize chest CT lung volumes to ensure precise diagnosis and monitoring of airway disease.
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