Evidence map›Paper›PMID 39613950›Full record

SynthesisTargeted oncology2025

Defining the Position of [

Chiara Ciccarese, Matteo Bauckneht, Luca Zagaria, Giuseppe Fornarini, Viria Beccia, Francesco Lanfranchi, Germano Perotti, Giada Pinterpe, Fortuna Migliaccio, Giampaolo Tortora and 5 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Targeted oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Efficacy, safety, and quality of life outcomes of [International urology and nephrology · 2026
    Review
  2. Article
  3. Review
  4. Frailty and [Theranostics · 2026
    Review
  5. Is [Cancers · 2025
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chiara Ciccarese *Medical Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Agostino Gemelli 8, 00168, Rome, Italy.ORCID https://orcid.org/0000-0002-3283-4339
Matteo Bauckneht *Department of Health Sciences (DISSAL), University of Genova, 16132, Genoa, Italy. matteo.bauckneht@unige.it.ORCID http://orcid.org/0000-0002-1937-9116
Luca ZagariaNuclear Medicine Unit, Department of Radiology and Oncological Radiotherapy, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168, Rome, Italy.
Giuseppe FornariniMedical Oncology 1, IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.ORCID https://orcid.org/0000-0003-4754-6572
Viria BecciaFaculty of Medicine, Università Cattolica del Sacro Cuore, Rome, Italy.
Francesco LanfranchiDepartment of Health Sciences (DISSAL), University of Genova, 16132, Genoa, Italy.ORCID https://orcid.org/0000-0002-6043-9627
Germano PerottiNuclear Medicine Unit, Department of Radiology and Oncological Radiotherapy, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168, Rome, Italy.
Giada PinterpeNuclear Medicine Unit, Department of Radiology and Oncological Radiotherapy, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168, Rome, Italy.
Fortuna MigliaccioNuclear Medicine Unit, Department of Radiology and Oncological Radiotherapy, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168, Rome, Italy.
Giampaolo TortoraMedical Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Agostino Gemelli 8, 00168, Rome, Italy.ORCID https://orcid.org/0000-0002-1378-4962
Lucia LeccisottiFaculty of Medicine, Università Cattolica del Sacro Cuore, Rome, Italy.ORCID https://orcid.org/0000-0002-6000-2898
Gianmario SambucetiDepartment of Health Sciences (DISSAL), University of Genova, 16132, Genoa, Italy.ORCID https://orcid.org/0000-0003-2979-6500
Alessandro GiordanoFaculty of Medicine, Università Cattolica del Sacro Cuore, Rome, Italy.
Orazio CaffoUnit of Oncology, Santa Chiara Regional Hospital, APSS, Trento, Italy.ORCID https://orcid.org/0000-0001-7968-2531
Roberto IacovelliMedical Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Agostino Gemelli 8, 00168, Rome, Italy.ORCID https://orcid.org/0000-0002-1750-2117

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn recent years, theranostics has become a promising approach for treating metastatic castration-resistant prostate cancer (mCRPC), with trials investigating targeted radioligand therapy, particularly using prostate-specific membrane antigen labeled with lutetium-177 ([ DESIGN, SETTING, AND

participantsWe conducted a systematic review and meta-analysis of phase II/III randomized controlled trials to assess the efficacy of [ OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Data were extracted according to the PRISMA statement. Summary hazard ratios (HRs) were calculated using random- or fixed-effects models. Statistical analyses were performed with RevMan software (v.5.2.3).

results[

conclusion[

Indexed as

LutetiumProstatic Neoplasms, Castration-ResistantRadioisotopesClinical Trials as TopicHumansMaleNeoplasm MetastasisLutetiumLutetium-177Radioisotopes

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.