ArticleNature chemistry2025
Phase separation and ageing of glycine-rich protein from tick adhesive.
Article in Nature chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Biomolecular coacervation-mediated materials: Phase states, phase transitions, and biomedical applications.Bioactive materials · 2027Review
- A biofilm-derived peptide as an underwater adhesive.bioRxiv : the preprint server for biology · 2026Article
- Review
- Surface-specific film assembly of a Vibrio cholerae adhesin-derived peptide modulated by environmental salts.bioRxiv : the preprint server for biology · 2026Article
- Dysregulation of liquid-liquid phase separation: from molecular mechanisms to targeted therapies in cardiovascular diseases.Journal of nanobiotechnology · 2026Review
- Biomolecular Condensates as Protein Degradation Tools for Intracellular Targets.Nature communications · 2026Article
- Silk-Inspired Design and Manufacturing of Robust Plantymers.Nature communications · 2026Article
- Bipartite DNA binding domain of transcription factor BCL11B binds clustered short DNA sequence motifs.bioRxiv : the preprint server for biology · 2026Article
- EBF2 condensates enable adipose thermogenesis through ZFP423 sequestration and epigenetic remodeling.Nature communications · 2026Article
- Vibrio choleraeadhesin-derived peptides mediate strong pull-off forces in aqueous media with high ionic strength.Colloids and surfaces. B, Biointerfaces · 2026Article
- Article
- Article
- Non-equilibrium demixing and dissolution of chiral coacervates via intrinsic catalysis.Nature communications · 2025Article
- The antifungal mechanism of EntV-derived peptides is associated with a reduction in extracellular vesicle release.PLoS pathogens · 2025Article
- Article
- Computational rheometry of viscoelastic networks: From random graphs to biomolecular condensates.bioRxiv : the preprint server for biology · 2025Article
- Article
- Numerical investigation of water droplet collision dynamics on moving surfaces.Scientific reports · 2025Article
- Coacervating proteins stick like a tick.Nature chemistry · 2025Article
- Phase separation and ageing of glycine-rich protein from tick adhesive.Nature chemistry · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Hard ticks feed on their host for multiple days. To ensure firm attachment, they secrete a protein-rich saliva that eventually forms a solid cement cone. The underlying mechanism of this liquid-to-solid transition is currently not understood. This study focuses on the phase transitions of a disordered glycine-rich protein (GRP) found in tick saliva. We show that GRP undergoes liquid-liquid phase separation via simple coacervation to form biomolecular condensates in salty environments. Cation-π and π-π interactions mediated by periodically placed arginine and aromatic amino-acid residues are the primary driving forces that promote phase separation. Interestingly, GRP condensates exhibit ageing by undergoing liquid-to-gel transition over time and exhibit adhesive properties, similar to the naturally occurring cement cone. Finally, we provide evidence for protein-rich condensates in natural tick saliva. Our findings provide a starting point to gain further insights into the bioadhesion of ticks, to develop novel tick control strategies, and towards achieving biomedical applications such as tissue sealants.
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Registered trials
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