Evidence map›Paper›PMID 39613865›Full record

ArticleScientific reports2024

Systemic inflammatory response in colorectal cancer is associated with tumour mismatch repair and impaired survival.

Mats Hjortborg, Sofia Edin, Camilla Böckelman, Tuomas Kaprio, Xingru Li, Ioannis Gkekas, Jaana Hagström, Karin Strigård, Caj Haglund, Ulf Gunnarsson and 1 more

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In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Define a good prognosis ofFrontiers in oncology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mats HjortborgDepartment of Diagnostics and Intervention, Umeå University, Umeå, Sweden.
Sofia EdinDepartment of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.
Camilla BöckelmanDepartment of Gastrointestinal Surgery, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.
Tuomas KaprioDepartment of Gastrointestinal Surgery, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.
Xingru LiDepartment of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.
Ioannis GkekasDepartment of Diagnostics and Intervention, Umeå University, Umeå, Sweden.
Jaana HagströmDepartment of Pathology, Department of Oral Pathology and Radiology, University of Helsinki, University of Turku, Helsinki, Finland.
Karin StrigårdDepartment of Diagnostics and Intervention, Umeå University, Umeå, Sweden.
Caj HaglundDepartment of Gastrointestinal Surgery, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.
Ulf GunnarssonDepartment of Diagnostics and Intervention, Umeå University, Umeå, Sweden.
Richard PalmqvistDepartment of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden. richard.palmqvist@umu.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The systemic inflammatory response (SIR), defined as elevated levels of circulating C-reactive protein (CRP), is an important predictor of impaired survival in colorectal cancer. The aim of this study was to explore the prognostic role of SIR and its association with tumour mismatch repair status and the immune response. Immune activity profiles of mononuclear cells isolated from CRC tissues and blood in the U-CAN exploration cohort (n = 69), were analysed by flow cytometry. In the U-CAN validation cohort (n = 257), T-helper cells (T-bet

Indexed as

Colorectal NeoplasmsC-Reactive ProteinDNA Mismatch RepairMicrosatellite InstabilityAdultAgedAged, 80 and overFemaleHumansInflammationMacrophagesMaleMiddle AgedPrognosisC-Reactive ProteinColorectal cancerImmunityMismatch repairPrognosisSystemic inflammatory response

Identifiers

PMID39613865
PMCPMC11607405

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.