Evidence map›Paper›PMID 39613837›Full record

ArticleScientific reports2024

Mycobacterium tuberculosis Rv1048c affects the biological characteristics of recombinant Mycobacterium smegmatis.

Dan-Ni Li, Xin-Yue Liu, Jin-Biao Xu, Kun Shi, Jian-Ming Li, Nai-Chao Diao, Ying Zong, Fan-Li Zeng, Rui Du

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PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dan-Ni Li *College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Xin-Yue Liu *College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Jin-Biao Xu *College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
Kun ShiCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
Jian-Ming LiCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
Nai-Chao DiaoCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
Ying ZongCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.
Fan-Li ZengCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China. zengfanli@jlau.edu.cn.
Rui DuCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China. durui@jlau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis is a serious, infectious, zoonotic disease caused by Mycobacterium tuberculosis. Infections are transmitted in humans and livestock via aerosols. Rv1048c is a hypothetical unknown protein in the standard strain of Mycobacterium tuberculosis H37Rv. Rv1048c exists only in pathogenic Mycobacterium tuberculosis and is highly conserved; however its function is still unclear. The recombinant Mycobacterium smegmatis strain Ms_Rv1048c, with heterologous expression of the Rv1048c gene, was constructed by using the pMV261 expression plasmid. The biological characteristics of the recombinant bacteria were studied, such as their growth pattern, drug resistance, and virulence. Expression of Rv1048c significantly reduced the growth rate of the strain, enhanced its ability to form a biofilm, and reduced its tolerance to sodium dodecyl sulfate, H

Indexed as

Bacterial ProteinsMycobacterium smegmatisMycobacterium tuberculosisAnimalsAntitubercular AgentsBiofilmsHumansHydrogen PeroxideMacrophagesMiceRAW 264.7 CellsVirulenceVirulence FactorsAntitubercular AgentsBacterial ProteinsHydrogen PeroxideVirulence FactorsBiological characteristicsMycobacterium smegmatisMycobacterium tuberculosisRecombinant plasmidRv1048c protein

Identifiers

PMID39613837
PMCPMC11607331

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.