Stress fiber strain is zero in normal aortic smooth muscle, elevated in hypertensive stretch, and minimal in wall thickening rats.

Shukei Sugita, Rintaro Kawai, Yoshihiro Ujihara, Masanori Nakamura

Abstract read

In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shukei SugitaDepartment of Electrical and Mechanical Engineering, Nagoya Institute of Technology, Gokiso-Cho, Showa-Ku, Nagoya, 466-8555, Japan. sugita.shukei@nitech.ac.jp.ORCID http://orcid.org/0000-0002-0922-2465

Rintaro KawaiDepartment of Electrical and Mechanical Engineering, Nagoya Institute of Technology, Gokiso-Cho, Showa-Ku, Nagoya, 466-8555, Japan.

Yoshihiro UjiharaDepartment of Electrical and Mechanical Engineering, Nagoya Institute of Technology, Gokiso-Cho, Showa-Ku, Nagoya, 466-8555, Japan.

Masanori NakamuraDepartment of Electrical and Mechanical Engineering, Nagoya Institute of Technology, Gokiso-Cho, Showa-Ku, Nagoya, 466-8555, Japan.

Funding

Japan Agency for Medical Research and Development JP20gm0810005Japan Society for the Promotion of Science 21H04955a

6 · The paper itself

Abstract

Hypertension causes aortic wall thickening until the original wall stress is restored. We hypothesized that this regulation involves stress fiber (SF) tension transmission to the nucleus in smooth muscle cells (SMCs) and investigated the strain in the SF direction as a condition required for this transmission. Thoracic aortas from Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHRs) were examined. SFs in aortic SMCs were fluorescently labeled and observed under a confocal microscope while stretched along the circumferential (θ) axis. Three conditions were studied: WKY physiological (WKY

Indexed as

HypertensionMuscle, Smooth, VascularRats, Inbred SHRRats, Inbred WKYStress FibersAnimalsAortaAorta, ThoracicBlood PressureMaleMyocytes, Smooth MuscleRatsStress, MechanicalFluorescent microscopyHypertensionNormal strainStress fiberVascular smooth muscle cells

Identifiers

PMID39613822

DOI10.1038/s41598-024-81229-w

PMCPMC11606938

What OpenQuestion holds

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.